Intrinsic disorder: A term to define the specific physicochemical characteristic of protein conformational heterogeneity

Edward A. Lemke, M. Madan Babu, Richard W. Kriwacki, Tanja Mittag, Rohit V. Pappu, Peter E. Wright, Julie D. Forman-Kay

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

In his commentary in this issue of Molecular Cell,1 Struhl reasons that the term “intrinsically disordered regions” represents a vague and confusing concept for protein function. However, the term “intrinsically disordered” highlights the important physicochemical characteristic of conformational heterogeneity. Thus, “intrinsically disordered” is the counterpart to the term “folded, ” with neither term having specific functional implications.

Original languageEnglish
Pages (from-to)1188-1190
Number of pages3
JournalMolecular cell
Volume84
Issue number7
DOIs
StatePublished - Apr 4 2024

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