Intravenous versus inhaled atropine for inhibiting bronchoconstrictor responses in dogs

M. J. Holtzman, M. P. McNamara, D. Sheppard, L. M. Fabbri, H. L. Hahn, P. D. Graf, J. A. Nadel

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

We studied whether the muscarinic antagonist, atropine, given intravenously or by inhalation, inhibits the bronchoconstrictor responses to inhaled acetylcholine and to acetylcholine released by electrical stimulation of the vagus nerves to the same degree. We assessed bronchoconstrictor responses in anesthetized dogs by determining the increase in total pulmonary resistance before and after increasing doses of atropine and then constructing inhibition dose-response curves. Before atropine the responses to the two stimuli were equal in magnitude. After intravenous atropine (initial dose 0.12 μg/kg, total dose, 16 μg/kg) both responses were progressively inhibited to a similar degree. By contrast, after inhaled atropine (initial dose 0.02 μg/kg, total dose 2.4 μg/kg) the response to acetylcholine inhalation was inhibited to a much greater degree than the response to vagal stimulation. Thus, in studies designed to inhibit bronchoconstriction due to an inhaled muscarinic agonist to the same degree as bronchoconstriction due to a vagal reflex, atropine might better be given intravenously than by inhalation.

Original languageEnglish
Pages (from-to)134-139
Number of pages6
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume54
Issue number1
StatePublished - May 26 1983
Externally publishedYes

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