TY - JOUR
T1 - Intraocular Pressure Response to Topical Epinephrine and HLA-B12
AU - Shin, Dong H.
AU - Kass, Michael A.
AU - Becker, Bernard
PY - 1978/6
Y1 - 1978/6
N2 - Twenty high responders to topical corticosteroids (intraocular pressure > 31 mm Hg after six weeks of topical 0.1% dexamethasone, four times daily) and 20 low responders (IOP < 20 mm Hg) of similar age, sex, race, initial IOP, and facility of outflow were selected. After 24 hours of treatment (two doses) of topical 1% epinephrine hydrochloride, the high corticosteroid responders showed a mean (±SD) corrected decrease in IOP of 3.6 ± 2.0 mm Hg as opposed to 1.8 ± 2.1 mm Hg in the low corticosteroid responders. Within both corticosteroid groups, individuals with the antigen HLA-B12 showed significantly greater decreases in IOP. This suggested that the presence of HLA-B12 was not only associated with increased responses to corticosteroids but also to epinephrine.
AB - Twenty high responders to topical corticosteroids (intraocular pressure > 31 mm Hg after six weeks of topical 0.1% dexamethasone, four times daily) and 20 low responders (IOP < 20 mm Hg) of similar age, sex, race, initial IOP, and facility of outflow were selected. After 24 hours of treatment (two doses) of topical 1% epinephrine hydrochloride, the high corticosteroid responders showed a mean (±SD) corrected decrease in IOP of 3.6 ± 2.0 mm Hg as opposed to 1.8 ± 2.1 mm Hg in the low corticosteroid responders. Within both corticosteroid groups, individuals with the antigen HLA-B12 showed significantly greater decreases in IOP. This suggested that the presence of HLA-B12 was not only associated with increased responses to corticosteroids but also to epinephrine.
UR - http://www.scopus.com/inward/record.url?scp=0017826247&partnerID=8YFLogxK
U2 - 10.1001/archopht.1978.03910050536007
DO - 10.1001/archopht.1978.03910050536007
M3 - Article
C2 - 655937
AN - SCOPUS:0017826247
SN - 0003-9950
VL - 96
SP - 1012
EP - 1013
JO - Archives of Ophthalmology
JF - Archives of Ophthalmology
IS - 6
ER -