Intramolecular hydroamination of dithioketene acetals: An easy route to cyclic amino acid derivatives

Hai Chao Xu; Kevin D. Moeller

doi:10.1021/ol102193x

Intramolecular hydroamination of dithioketene acetals: An easy route to cyclic amino acid derivatives

Hai Chao Xu, Kevin D. Moeller

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Abstract

Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.

Original language	English
Pages (from-to)	5174-5177
Number of pages	4
Journal	Organic Letters
Volume	12
Issue number	22
DOIs	https://doi.org/10.1021/ol102193x
State	Published - Nov 19 2010

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title = "Intramolecular hydroamination of dithioketene acetals: An easy route to cyclic amino acid derivatives",

abstract = "Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.",

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AU - Moeller, Kevin D.

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N2 - Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.

AB - Catalytic intramolecular hydroamination of dithioketene acetals was developed for the synthesis of cyclic amino acid derivatives. Triggered by the addition of a catalytical amount of n-BuLi, the reaction proceeds to give proline and pipecolic acid derivatives in excellent yields and diastereoselectivity.

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U2 - 10.1021/ol102193x

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JO - Organic Letters

JF - Organic Letters

IS - 22

ER -

Intramolecular hydroamination of dithioketene acetals: An easy route to cyclic amino acid derivatives

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