Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Matthew K. Hensley; William G. Bain; Jana Jacobs; Sham Nambulli; Urvi Parikh; Anthony Cillo; Brittany Staines; Amy Heaps; Michele D. Sobolewski; Linda J. Rennick; Bernard J.C. MacAtangay; Cynthia Klamar-Blain; Georgios D. Kitsios; Barbara Methé; Ashwin Somasundaram; Tullia C. Bruno; Carly Cardello; Feng Shan; Creg Workman; Prabir Ray; Anuradha Ray; Janet Lee; Rahil Sethi; William E. Schwarzmann; Mark S. Ladinsky; Pamela J. Bjorkman; Dario A. Vignali; W. Paul Duprex; Mounzer E. Agha; John W. Mellors; Kevin D. McCormick; Alison Morris; Ghady Haidar

doi:10.1093/cid/ciab072

Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Matthew K. Hensley
, William G. Bain
, Jana Jacobs
, Sham Nambulli
, Urvi Parikh
, Anthony Cillo
, Brittany Staines
, Amy Heaps
, Michele D. Sobolewski
, Linda J. Rennick
, Bernard J.C. MacAtangay
, Cynthia Klamar-Blain
, Georgios D. Kitsios
, Barbara Methé
, Ashwin Somasundaram
, Tullia C. Bruno
, Carly Cardello
, Feng Shan
, Creg Workman
, Prabir Ray

Anuradha Ray, Janet Lee, Rahil Sethi, William E. Schwarzmann, Mark S. Ladinsky, Pamela J. Bjorkman, Dario A. Vignali, W. Paul Duprex, Mounzer E. Agha, John W. Mellors, Kevin D. McCormick, Alison Morris, Ghady Haidar

Research output: Contribution to journal › Article › peer-review

112 Scopus citations

Abstract

A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

Original language	English
Pages (from-to)	E815-E821
Journal	Clinical Infectious Diseases
Volume	73
Issue number	3
DOIs	https://doi.org/10.1093/cid/ciab072
State	Published - Aug 1 2021

Keywords

COVID-19
SARS-CoV-2 RNAemia
SARS-CoV-2 immune responses
SARS-CoV-2 infectivity
SARS-CoV-2 intrahost variation
severe acute respiratory syndrome coronavirus 2

Access to Document

10.1093/cid/ciab072

Fingerprint

Dive into the research topics of 'Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study'. Together they form a unique fingerprint.

Cite this

Hensley, M. K., Bain, W. G., Jacobs, J., Nambulli, S., Parikh, U., Cillo, A., Staines, B., Heaps, A., Sobolewski, M. D., Rennick, L. J., MacAtangay, B. J. C., Klamar-Blain, C., Kitsios, G. D., Methé, B., Somasundaram, A., Bruno, T. C., Cardello, C., Shan, F., Workman, C., ... Haidar, G. (2021). Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study. Clinical Infectious Diseases, 73(3), E815-E821. https://doi.org/10.1093/cid/ciab072

@article{a6458130f38c4bacab8cf9270199902f,

title = "Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study",

abstract = "A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.",

keywords = "COVID-19, SARS-CoV-2 RNAemia, SARS-CoV-2 immune responses, SARS-CoV-2 infectivity, SARS-CoV-2 intrahost variation, severe acute respiratory syndrome coronavirus 2",

author = "Hensley, \{Matthew K.\} and Bain, \{William G.\} and Jana Jacobs and Sham Nambulli and Urvi Parikh and Anthony Cillo and Brittany Staines and Amy Heaps and Sobolewski, \{Michele D.\} and Rennick, \{Linda J.\} and MacAtangay, \{Bernard J.C.\} and Cynthia Klamar-Blain and Kitsios, \{Georgios D.\} and Barbara Meth{\'e} and Ashwin Somasundaram and Bruno, \{Tullia C.\} and Carly Cardello and Feng Shan and Creg Workman and Prabir Ray and Anuradha Ray and Janet Lee and Rahil Sethi and Schwarzmann, \{William E.\} and Ladinsky, \{Mark S.\} and Bjorkman, \{Pamela J.\} and Vignali, \{Dario A.\} and \{Paul Duprex\}, W. and Agha, \{Mounzer E.\} and Mellors, \{John W.\} and McCormick, \{Kevin D.\} and Alison Morris and Ghady Haidar",

year = "2021",

month = aug,

day = "1",

doi = "10.1093/cid/ciab072",

language = "English",

volume = "73",

pages = "E815--E821",

journal = "Clinical Infectious Diseases",

issn = "1058-4838",

number = "3",

}

Hensley, MK, Bain, WG, Jacobs, J, Nambulli, S, Parikh, U, Cillo, A, Staines, B, Heaps, A, Sobolewski, MD, Rennick, LJ, MacAtangay, BJC, Klamar-Blain, C, Kitsios, GD, Methé, B, Somasundaram, A, Bruno, TC, Cardello, C, Shan, F, Workman, C, Ray, P, Ray, A, Lee, J, Sethi, R, Schwarzmann, WE, Ladinsky, MS, Bjorkman, PJ, Vignali, DA, Paul Duprex, W, Agha, ME, Mellors, JW, McCormick, KD, Morris, A & Haidar, G 2021, 'Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study', Clinical Infectious Diseases, vol. 73, no. 3, pp. E815-E821. https://doi.org/10.1093/cid/ciab072

Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study. / Hensley, Matthew K.; Bain, William G.; Jacobs, Jana et al.
In: Clinical Infectious Diseases, Vol. 73, No. 3, 01.08.2021, p. E815-E821.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient

T2 - A Case Study

AU - Hensley, Matthew K.

AU - Bain, William G.

AU - Jacobs, Jana

AU - Nambulli, Sham

AU - Parikh, Urvi

AU - Cillo, Anthony

AU - Staines, Brittany

AU - Heaps, Amy

AU - Sobolewski, Michele D.

AU - Rennick, Linda J.

AU - MacAtangay, Bernard J.C.

AU - Klamar-Blain, Cynthia

AU - Kitsios, Georgios D.

AU - Methé, Barbara

AU - Somasundaram, Ashwin

AU - Bruno, Tullia C.

AU - Cardello, Carly

AU - Shan, Feng

AU - Workman, Creg

AU - Ray, Prabir

AU - Ray, Anuradha

AU - Lee, Janet

AU - Sethi, Rahil

AU - Schwarzmann, William E.

AU - Ladinsky, Mark S.

AU - Bjorkman, Pamela J.

AU - Vignali, Dario A.

AU - Paul Duprex, W.

AU - Agha, Mounzer E.

AU - Mellors, John W.

AU - McCormick, Kevin D.

AU - Morris, Alison

AU - Haidar, Ghady

PY - 2021/8/1

Y1 - 2021/8/1

N2 - A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

AB - A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.

KW - COVID-19

KW - SARS-CoV-2 RNAemia

KW - SARS-CoV-2 immune responses

KW - SARS-CoV-2 infectivity

KW - SARS-CoV-2 intrahost variation

KW - severe acute respiratory syndrome coronavirus 2

UR - https://www.scopus.com/pages/publications/85113712510

U2 - 10.1093/cid/ciab072

DO - 10.1093/cid/ciab072

M3 - Article

C2 - 33507235

AN - SCOPUS:85113712510

SN - 1058-4838

VL - 73

SP - E815-E821

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 3

ER -

Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this