@article{a6458130f38c4bacab8cf9270199902f,
title = "Intractable Coronavirus Disease 2019 (COVID-19) and Prolonged Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Replication in a Chimeric Antigen Receptor-Modified T-Cell Therapy Recipient: A Case Study",
abstract = "A chimeric antigen receptor-modified T-cell therapy recipient developed severe coronavirus disease 2019, intractable RNAemia, and viral replication lasting >2 months. Premortem endotracheal aspirate contained >2 × 1010 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA copies/mL and infectious virus. Deep sequencing revealed multiple sequence variants consistent with intrahost virus evolution. SARS-CoV-2 humoral and cell-mediated immunity were minimal. Prolonged transmission from immunosuppressed patients is possible.",
keywords = "COVID-19, SARS-CoV-2 RNAemia, SARS-CoV-2 immune responses, SARS-CoV-2 infectivity, SARS-CoV-2 intrahost variation, severe acute respiratory syndrome coronavirus 2",
author = "Hensley, {Matthew K.} and Bain, {William G.} and Jana Jacobs and Sham Nambulli and Urvi Parikh and Anthony Cillo and Brittany Staines and Amy Heaps and Sobolewski, {Michele D.} and Rennick, {Linda J.} and MacAtangay, {Bernard J.C.} and Cynthia Klamar-Blain and Kitsios, {Georgios D.} and Barbara Meth{\'e} and Ashwin Somasundaram and Bruno, {Tullia C.} and Carly Cardello and Feng Shan and Creg Workman and Prabir Ray and Anuradha Ray and Janet Lee and Rahil Sethi and Schwarzmann, {William E.} and Ladinsky, {Mark S.} and Bjorkman, {Pamela J.} and Vignali, {Dario A.} and {Paul Duprex}, W. and Agha, {Mounzer E.} and Mellors, {John W.} and McCormick, {Kevin D.} and Alison Morris and Ghady Haidar",
note = "Funding Information: Financial support. Research reported in this publication was supported by the National Center for Advancing Translational Sciences of the National Institutes of Health (NIH) (award number KL2TR001856 to G. H.); the United States Department of Veterans Affairs Biomedical Laboratory R&D Service (career development award number IK2 BX004886 to W. B.); the NIH (grant number P50 8 P50 AI150464–13 to P. J. B.); George Mason University Fast Grants (to P. J. B.); the Center for Vaccine Research/University of Pittsburgh (grant numbers P01HL114453 to P. R. and J. S. L. and R01 HL136143 to J. S. L.); and the University of Pittsburgh Medical Center P01 AI108545, P50 CA097190 & R01s CA203689, DK089125, AI129893, and AI144422 (to D. A. V.). Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.",
year = "2021",
month = aug,
day = "1",
doi = "10.1093/cid/ciab072",
language = "English",
volume = "73",
pages = "E815--E821",
journal = "Clinical Infectious Diseases",
issn = "1058-4838",
number = "3",
}