Intracranial ependymomas of childhood: Current management strategies

Matthew D. Smyth, Biljana N. Horn, Carolyn Russo, Mitchel S. Berger

Research output: Contribution to journalArticlepeer-review

52 Scopus citations


Children with intracranial ependymomas have relatively poor outcomes despite the low-grade histology of these tumors and recent advances in diagnosis, microneurosurgical resection, and adjuvant therapy. Aggressive surgical resection and postoperative adjuvant therapy result in only a 5-year survival rate of 50%. In this paper, we provide a review of the current technical aspects of surgical resection, and focus on recent studies of the epidemiology, molecular markers, prognostic factors and adjuvant therapy for childhood intracranial ependymomas and discuss their implications for current and future management strategies. Copyright (C) 2000 S. Karger AG, Basel.

Original languageEnglish
Pages (from-to)138-150
Number of pages13
JournalPediatric Neurosurgery
Issue number3
StatePublished - Jan 1 2000


  • Brain tumor
  • Children
  • Ependymoma
  • Review
  • Surgery


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