Circadian clocks are present in most organisms and provide an adaptive mechanism to coordinate physiology and behavior with predictable changes in the environment. Genetic, biochemical, and cellular experiments have identified more than a dozen component genes and a signal transduction pathway that support cell-autonomous, circadian clock function. One of the hallmarks of biological clocks is their ability to reset to relevant stimuli while ignoring most others. We review recent results showing intracellular and intercellular mechanisms that convey this robust timekeeping to a variety of circadian cell types.

Original languageEnglish
Pages (from-to)1427-1434
Number of pages8
JournalFEBS Letters
Issue number10
StatePublished - May 20 2011


  • Circadian clock
  • Genetic architecture
  • Intercellular
  • Intracellular
  • Network
  • Neuropeptides
  • Oscillator
  • Robustness
  • Signaling


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