Intracellular acidification induces decrease of cytosolic calcium in isolated osteoclasts.

A. Teti, M. Grano, S. L. Teitelbaum, K. A. Hruska, S. Colucci, A. Zambonin Zallone

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Abstract

In this study the effects of changes in intracellular pH on cytosolic Ca2+ were examined in single isolated osteoclasts. Alkalinization, performed by incubation in HCO3 containing buffer, induced increases in [Ca2+]. Conversely acidification, obtained by incubation in Na-butyrate-containing buffer induced a rapid and sustained decrease of [Ca2+]. The decrease of [Ca2+], during acidification with Na-butyrate was inhibited by VO4, an inhibitor of the Ca2+-ATPase. All these pieces of information indicate that changes in pH1 can modulate osteoclast activity together with modifications of [Ca2+], probably acting as intracellular signals.

Original languageEnglish
Pages (from-to)689-693
Number of pages5
JournalBollettino della Societa italiana di biologia sperimentale
Volume65
Issue number8
StatePublished - Aug 1 1989
Externally publishedYes

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