Intra-patient comparison of physiologic 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

Medhat M. Osman; Amir Iravani; Michael S. Hofman; Rodney J. Hicks

doi:10.1186/s40644-021-00404-8

Intra-patient comparison of physiologic ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

Medhat M. Osman, Amir Iravani, Michael S. Hofman, Rodney J. Hicks

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Background: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing ⁶⁸Ga -PSMA-11 and in 96.9% of patients undergoing ¹⁸F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with ¹⁸F-DCFPyL compared to ⁶⁸Ga-PSMA-11. This includes more frequent visualization of cervical and sacral ganglia, which may be attributable to better imaging characteristics with ¹⁸F PET imaging. Case presentation: This pictorial essay is to illustrate and compare, in the same patient, various representative cases of ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL PET/CT uptake in ganglia at different anatomic locations, with different patterns and distribution of metabolic activity. Conclusion: Reading physicians should be aware of the frequently encountered and occasionally different physiologic uptake of ⁶⁸Ga-PSMA-11 and ¹⁸F DCFPyL in different ganglia.

Original language	English
Article number	35
Journal	Cancer Imaging
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s40644-021-00404-8
State	Published - Dec 2021

Keywords

F-DCFPyL PET/CT
Ga-PSMA11 PET/CT
Ganglia
PSMA

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title = "Intra-patient comparison of physiologic 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay",

abstract = "Background: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing 68Ga -PSMA-11 and in 96.9% of patients undergoing 18F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with 18F-DCFPyL compared to 68Ga-PSMA-11. This includes more frequent visualization of cervical and sacral ganglia, which may be attributable to better imaging characteristics with 18F PET imaging. Case presentation: This pictorial essay is to illustrate and compare, in the same patient, various representative cases of 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia at different anatomic locations, with different patterns and distribution of metabolic activity. Conclusion: Reading physicians should be aware of the frequently encountered and occasionally different physiologic uptake of 68Ga-PSMA-11 and 18F DCFPyL in different ganglia.",

keywords = "F-DCFPyL PET/CT, Ga-PSMA11 PET/CT, Ganglia, PSMA",

author = "Osman, {Medhat M.} and Amir Iravani and Hofman, {Michael S.} and Hicks, {Rodney J.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",

year = "2021",

month = dec,

doi = "10.1186/s40644-021-00404-8",

language = "English",

volume = "21",

journal = "Cancer Imaging",

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T1 - Intra-patient comparison of physiologic 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients

T2 - a pictorial essay

AU - Osman, Medhat M.

AU - Iravani, Amir

AU - Hofman, Michael S.

AU - Hicks, Rodney J.

PY - 2021/12

Y1 - 2021/12

N2 - Background: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing 68Ga -PSMA-11 and in 96.9% of patients undergoing 18F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with 18F-DCFPyL compared to 68Ga-PSMA-11. This includes more frequent visualization of cervical and sacral ganglia, which may be attributable to better imaging characteristics with 18F PET imaging. Case presentation: This pictorial essay is to illustrate and compare, in the same patient, various representative cases of 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia at different anatomic locations, with different patterns and distribution of metabolic activity. Conclusion: Reading physicians should be aware of the frequently encountered and occasionally different physiologic uptake of 68Ga-PSMA-11 and 18F DCFPyL in different ganglia.

AB - Background: Recent studies reported metabolic uptake in at least one of the evaluated ganglia in 98.5% of patients undergoing 68Ga -PSMA-11 and in 96.9% of patients undergoing 18F-DCFPyL PET/CT examination. We have observed different patterns of ganglion visualization with 18F-DCFPyL compared to 68Ga-PSMA-11. This includes more frequent visualization of cervical and sacral ganglia, which may be attributable to better imaging characteristics with 18F PET imaging. Case presentation: This pictorial essay is to illustrate and compare, in the same patient, various representative cases of 68Ga-PSMA-11 and 18F-DCFPyL PET/CT uptake in ganglia at different anatomic locations, with different patterns and distribution of metabolic activity. Conclusion: Reading physicians should be aware of the frequently encountered and occasionally different physiologic uptake of 68Ga-PSMA-11 and 18F DCFPyL in different ganglia.

KW - F-DCFPyL PET/CT

KW - Ga-PSMA11 PET/CT

KW - Ganglia

KW - PSMA

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DO - 10.1186/s40644-021-00404-8

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AN - SCOPUS:85104421972

SN - 1470-7330

VL - 21

JO - Cancer Imaging

JF - Cancer Imaging

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M1 - 35

ER -

Intra-patient comparison of physiologic ⁶⁸Ga-PSMA-11 and ¹⁸F-DCFPyL PET/CT uptake in ganglia in prostate cancer patients: a pictorial essay

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