TY - JOUR
T1 - Intra-articular Implantation of Mesenchymal Stem Cells, Part 1
T2 - A Review of the Literature for Prevention of Postmeniscectomy Osteoarthritis
AU - Kraeutler, Matthew J.
AU - Mitchell, Justin J.
AU - Chahla, Jorge
AU - McCarty, Eric C.
AU - Pascual-Garrido, Cecilia
N1 - Publisher Copyright:
© 2017, © The Author(s) 2017.
PY - 2017/1/19
Y1 - 2017/1/19
N2 - Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings. Several studies in various animal models have evaluated the effect of injecting MSCs into the knee joints of animals with OA induced either by meniscal excision with or without anterior cruciate ligament transection. When compared with control groups receiving injections without progenitor cells, short-term benefits in the experimental groups have been reported. In human subjects, there are limited data to determine the effect of biological therapies for use in delaying or preventing the onset of OA after a meniscectomy procedure. The purpose of this review is to highlight the findings in the presently available literature on the use of intra-articular implantation of MSCs postmeniscectomy and to offer suggestions for future research with the goal of delaying or treating early OA postmeniscectomy with MSCs.
AB - Osteoarthritis (OA) after a partial or total meniscectomy procedure is a common pathology. Because of the high incidence of meniscectomy in the general population, as well as the significant burden of knee OA, there is increasing interest in determining methods for delaying postmeniscectomy OA. Biological therapies, including mesenchymal stem cells (MSCs), induced pluripotent stem cells (iPSCs), and platelet-rich plasma (PRP), have been proposed as possible therapies that could delay OA in this and other settings. Several studies in various animal models have evaluated the effect of injecting MSCs into the knee joints of animals with OA induced either by meniscal excision with or without anterior cruciate ligament transection. When compared with control groups receiving injections without progenitor cells, short-term benefits in the experimental groups have been reported. In human subjects, there are limited data to determine the effect of biological therapies for use in delaying or preventing the onset of OA after a meniscectomy procedure. The purpose of this review is to highlight the findings in the presently available literature on the use of intra-articular implantation of MSCs postmeniscectomy and to offer suggestions for future research with the goal of delaying or treating early OA postmeniscectomy with MSCs.
KW - knee osteoarthritis
KW - meniscectomy
KW - mesenchymal stem cells
KW - osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=85011884940&partnerID=8YFLogxK
U2 - 10.1177/2325967116680815
DO - 10.1177/2325967116680815
M3 - Review article
C2 - 28203597
AN - SCOPUS:85011884940
SN - 2325-9671
VL - 5
JO - Orthopaedic Journal of Sports Medicine
JF - Orthopaedic Journal of Sports Medicine
IS - 1
ER -