Intra-abdominal Sepsis: Newer Interventional and Antimicrobial Therapies

Joseph S. Solomkin, John Mazuski

Research output: Contribution to journalReview articlepeer-review

36 Scopus citations


Complicated intra-abdominal infections are the second most common cause of septic death in the intensive care unit. Although there have been improvements in the outcome of sepsis regardless of etiology, this is even more striking for intra-abdominal infections. From observation, recent advances in interventional techniques, including more aggressive use of percutaneous drainage of abscesses and use of "open abdomen" techniques for peritonitis, have significantly affected the morbidity and mortality of physiologically severe complicated intra-abdominal infection.

Original languageEnglish
Pages (from-to)593-608
Number of pages16
JournalInfectious disease clinics of North America
Issue number3
StatePublished - Sep 2009


  • Abscess
  • Antibiotic
  • Microbiology
  • Percutaneous drainage
  • Peritonitis
  • Severity
  • Source control


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