Intestinal IL-17R signaling controls secretory IgA and oxidase balance in citrobacter rodentium infection

Yasuka Matsunaga, Trevon Clark, Alanna G. Wanek, Jacob P. Bitoun, Qingqing Gong, Misty Good, Jay K. Kolls

Research output: Contribution to journalArticlepeer-review

Abstract

Type 17 cytokines have been strongly implicated in mucosal immunity, in part by regulating the production of antimicrobial peptides. Using a mouse model of Citrobacter rodentium infection, which causes colitis, we found that intestinal IL-17RA and IL-17RC were partially required for control of infection in the colon and IL-17 regulates the production of luminal hydrogen peroxide as well as expression of Tnsf13. Reduced Tnfsf13 expression was associated with a profound defect in generating C. rodentium–specific IgA+ Ab-secreting cells. Taken together, intestinal IL-17R signaling plays key roles in controlling invading pathogens, in part by regulating luminal hydrogen peroxide as well as regulating the generation of pathogen-specific IgA+ Ab-secreting cells.

Original languageEnglish
Pages (from-to)766-775
Number of pages10
JournalJournal of Immunology
Volume206
Issue number4
DOIs
StatePublished - Feb 15 2021

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