TY - JOUR
T1 - Intestinal epithelial cell differentiation
T2 - new insights from mice, flies and nematodes
AU - Simon, Theodore C.
AU - Gordon, Jeffrey I.
N1 - Funding Information:
We are indebted to members of our lab for their many insights regarding intestinal epithelial biology. Work from the authors’ lab cited in this manuscript was supported in part by National Institutes of Health grants DK37960 and DK30292.
PY - 1995/10
Y1 - 1995/10
N2 - Decisions commonly made during development that affect proliferation, cell fate specification, differentiation, migration, and death are made repeatedly in the mouse small intestinal epithelium throughout adulthood. The results of these decisions are a stratification of proliferation, differentiation, and death along the mouse small intestine's crypt/villus axis. Recent genetic studies in Caenorhabditis elegans and Drosophila melanogaster have identified factors involved in determining cell fate and differentiation in gut endoderm. The stem cell hierarchy of the adult mouse intestinal epithelium makes it ideally suited for using chimeric animals to examine the functions of homologs of these lower eukaryotic (and other) proteins.
AB - Decisions commonly made during development that affect proliferation, cell fate specification, differentiation, migration, and death are made repeatedly in the mouse small intestinal epithelium throughout adulthood. The results of these decisions are a stratification of proliferation, differentiation, and death along the mouse small intestine's crypt/villus axis. Recent genetic studies in Caenorhabditis elegans and Drosophila melanogaster have identified factors involved in determining cell fate and differentiation in gut endoderm. The stem cell hierarchy of the adult mouse intestinal epithelium makes it ideally suited for using chimeric animals to examine the functions of homologs of these lower eukaryotic (and other) proteins.
UR - http://www.scopus.com/inward/record.url?scp=0029144417&partnerID=8YFLogxK
U2 - 10.1016/0959-437X(95)80026-3
DO - 10.1016/0959-437X(95)80026-3
M3 - Article
C2 - 8664545
AN - SCOPUS:0029144417
SN - 0959-437X
VL - 5
SP - 577
EP - 586
JO - Current Opinion in Genetics and Development
JF - Current Opinion in Genetics and Development
IS - 5
ER -