TY - JOUR
T1 - Intestinal calcium transport
T2 - The role of sodium
AU - Birge, Stanley J.
AU - Gilbert, Helen R.
AU - Avioli, Louis V.
PY - 1972
Y1 - 1972
N2 - The role of sodium in intestinal calcium transport was investigated in everted rat intestine. Ethacrynic acid, but not ouabain, inhibited calcium transport. However, ouabain did inhibit net water transport and, therefore, sodium transport, establishing the dissociation of the two transport processes. In addition to a magnesium-dependent adenosine triphosphatase (activated by sodium and potassium), a phosphatase dependent on sodium and calcium was localized to the lateral and basal membrane fractions of the mucosal cell. Activity of the latter phosphatase, similar to calcium transport in intact tissue, was inhibited by ethacrynic acid and not by ouabain. Sodium, therefore, may participate in the calcium transport process by activating an enzyme complex, dependent on adenosine triphosphate, that mediates calcium transport.
AB - The role of sodium in intestinal calcium transport was investigated in everted rat intestine. Ethacrynic acid, but not ouabain, inhibited calcium transport. However, ouabain did inhibit net water transport and, therefore, sodium transport, establishing the dissociation of the two transport processes. In addition to a magnesium-dependent adenosine triphosphatase (activated by sodium and potassium), a phosphatase dependent on sodium and calcium was localized to the lateral and basal membrane fractions of the mucosal cell. Activity of the latter phosphatase, similar to calcium transport in intact tissue, was inhibited by ethacrynic acid and not by ouabain. Sodium, therefore, may participate in the calcium transport process by activating an enzyme complex, dependent on adenosine triphosphate, that mediates calcium transport.
UR - http://www.scopus.com/inward/record.url?scp=0015505650&partnerID=8YFLogxK
U2 - 10.1126/science.176.4031.168
DO - 10.1126/science.176.4031.168
M3 - Article
C2 - 4259233
AN - SCOPUS:0015505650
VL - 176
SP - 168
EP - 170
JO - Science
JF - Science
SN - 0036-8075
IS - 4031
ER -