Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk

Research output: Contribution to journalComment/debate

Abstract

Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.

Original languageEnglish
Article numbere1069917
JournalMolecular and Cellular Oncology
Volume3
Issue number3
DOIs
StatePublished - May 3 2016

Keywords

  • Adenylate cyclase
  • Neurofibromatosis 1
  • cAMP
  • glioma
  • sexual dimorphism

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