Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk

Joshua B. Rubin

doi:10.1080/23723556.2015.1069917

Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk

Joshua B. Rubin

Research output: Contribution to journal › Comment/debate

2 Scopus citations

Abstract

Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.

Original language	English
Article number	e1069917
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2015.1069917
State	Published - May 3 2016

Keywords

Adenylate cyclase
Neurofibromatosis 1
cAMP
glioma
sexual dimorphism

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10.1080/23723556.2015.1069917

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abstract = "Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.",

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AB - Cancer predisposition syndromes, particularly neurofibromatosis type 1 (NF1), provide unique vantage points from which to examine the co-contributions of molecular, cellular, and tissue processes to tumor biology. Polymorphisms in adenylate cyclase 8 affect brain tumor risk in NF1 in a sex-specific fashion, illuminating novel interdependencies in brain tumorigenesis.

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KW - cAMP

KW - glioma

KW - sexual dimorphism

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Intersections at the crossroads: Neurofibromatosis type 1, cAMP, sex, and glioma risk

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