Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability

Keyphrases

• Protein Interactome 100%
• Specific Vulnerability 100%
• Phosphatidylinositol 4-kinase (PI4K) 100%
• KRAS Signaling 40%
• Cas9 Protein 20%
• Loss Function 20%
• Specificity Protein 1 20%
• Interactome 20%
• Specific Interactions 20%
• Human Cancer 20%
• Interaction Partner 20%
• Function Test 20%
• Oncogenic Activity 20%
• Pancreatic Cancer Cell Lines 20%
• RAS Inhibitors 20%
• MAPK Inhibitors 20%
• Oncogenic mutations 20%
• Proximity-dependent Biotin Identification 20%
• KRAS-mutant Cancer 20%
• BirA 20%
• Druggable Proteins 20%
• Phosphatidylinositol Phosphate Kinase 20%
• Unique Regions 20%
• RAS Genes 20%

Biochemistry, Genetics and Molecular Biology

• Interactome 100%
• Isoform 100%
• KRAS 100%
• Carcinogenesis 30%
• HRAS 20%
• Mitogen-Activated Protein Kinase 10%
• Cancer Cell 10%
• Kinase 10%
• Phosphotransferase 10%
• CRISPR/Cas9 10%
• Biotin Identification 10%
• Phosphatidylinositol Phosphate 10%
• Oncogenic activity 10%