Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Chromatin reader protein BRD4 is thought to bookmark mitotic chromatin to propagate transcriptional states across mitosis. Behera et al. profiled and perturbed mitotic BRD4 chromatin occupancy to show that BRD4 is dispensable for this process. Instead, BRD4 mitotic chromatin association is likely a mere reflection of mitotically stable histone marks.

Original languageEnglish
Pages (from-to)400-415.e5
JournalCell Reports
Volume27
Issue number2
DOIs
StatePublished - Apr 9 2019

Keywords

  • BRD4
  • cell identity
  • erythroid cells
  • histone marks
  • mitosis
  • mitotic bookmarking

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