Interpreting mammalian target of rapamycin and cell growth inhibition in a genetically engineered mouse model of Nf1-deficient astrocytes

Keyphrases

• 4E-BP1 20%
• Astrocytes 100%
• Cell Growth Inhibition 100%
• Clinical Trials 20%
• Clinically Significant 20%
• Dose-dependent 20%
• Durable Response 20%
• Exponential Relationship 20%
• Genetically Engineered Mouse Models 100%
• Glial Cell Proliferation 20%
• Glial Cells 20%
• Growth Suppression 20%
• Jagged1 20%
• Ki-67 20%
• Kinase Inhibition 20%
• Mammalian Target of Rapamycin (mTOR) 100%
• Mammalian Target of Rapamycin Signaling Pathway 20%
• MTOR Inhibitor 20%
• Neurofibromatosis Type 1 (NF-1) 20%
• Optic Pathway Glioma 20%
• P-STAT3 20%
• Pathway Inhibitors 20%
• Phospho-S6 20%
• Phosphoinositide 3-kinase (PI3K) 40%
• Preclinical Data 20%
• Rapamycin 100%
• Rapamycin Analogs 20%
• Rapamycin Treatment 60%
• Suppression Effect 20%
• Targeted Inhibition 20%
• Targeting Effect 20%
• Treatment Response 20%
• Tumor Growth 20%
• Tumor Growth Inhibition 20%
• Tumor Proliferation 20%

Neuroscience

• Astrocyte 100%
• Biological Marker 22%
• Cell Growth 100%
• Cell Proliferation 11%
• Glial Cells 11%
• Glioma 11%
• In Vitro 11%
• In Vivo 22%
• Mammalian Target of Rapamycin 100%
• Microglia 11%
• Neurofibromatosis Type 1 11%
• Optics 11%
• Phosphoinositide 3-Kinase 22%
• Protein Jagged 1 11%
• Protein Kinase B 11%
• Sirolimus 100%
• STAT3 11%