Interplay of ryanodine receptor distribution and calcium dynamics

Leighton T. Izu, Shawn A. Means, John N. Shadid, Ye Chen-Izu, C. William Balke

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca 2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.

Original languageEnglish
Pages (from-to)95-112
Number of pages18
JournalBiophysical Journal
Issue number1
StatePublished - 2006


Dive into the research topics of 'Interplay of ryanodine receptor distribution and calcium dynamics'. Together they form a unique fingerprint.

Cite this