@article{69a9fec3029f4eceacdd88d851a8c492,
title = "Interplay of ryanodine receptor distribution and calcium dynamics",
abstract = "Spontaneously generated calcium (Ca2+) waves can trigger arrhythmias in ventricular and atrial myocytes. Yet, Ca2+ waves also serve the physiological function of mediating global Ca2+ increase and muscle contraction in atrial myocytes. We examine the factors that influence Ca2+ wave initiation by mathematical modeling and large-scale computational (supercomputer) simulations. An important finding is the existence of a strong coupling between the ryanodine receptor distribution and Ca 2+ dynamics. Even modest changes in the ryanodine receptor spacing profoundly affect the probability of Ca2+ wave initiation. As a consequence of this finding, we suggest that there is information flow from the contractile system to the Ca2+ control system and this dynamical interplay could contribute to the increased incidence of arrhythmias during heart failure.",
author = "Izu, {Leighton T.} and Means, {Shawn A.} and Shadid, {John N.} and Ye Chen-Izu and Balke, {C. William}",
note = "Funding Information: This work was supported in part by National Institutes of Health grants K25HL068704 (L.T.I.), RO1HL68733 (C.W.B.), RO1HL50435-05 (C.W.B.), RO1HL071865 (C.W.B. and L.T.I.), Veterans Administration Merit Review Award (C.W.B. and L.T.I.), National Center for Supercomputing Applications MCB00006N (L.T.I. and C.W.B.), and American Heart Association Scientist Development Grant 0335250N (Y.C.). This work was partially funded by the Department of Energy Office of Science Mathematical, Information, and Computational Sciences Division program at Sandia National Laboratory. Sandia is a multi-program laboratory operated by Sandia Corporation, a Lockheed Martin Company, for the United States Department of Energy{\textquoteright}s National Nuclear Security Administration under contract DE-AC04-94AL85000. ",
year = "2006",
doi = "10.1529/biophysj.105.077214",
language = "English",
volume = "91",
pages = "95--112",
journal = "Biophysical Journal",
issn = "0006-3495",
number = "1",
}