Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans

P. E. Cryer; A. Avogaro; D. M. Bier

Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans

P. E. Cryer, A. Avogaro, D. M. Bier

Endocrinology, Metabolism & Lipid Research

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

There is substantial evidence to support the view that epinephrine is a biologically important hormone of the adrenal medullae in humans. The hyperglycemic effect of epinephrine involves both direct and indirect actions, the latter including limitation of insulin secretion. However, increased insulin secretion, albeit restrained, occurs during sustained hyperepinephrinemia and limits the magnitude of glycemic response. In sharp contrast, increased insulin secretion does not limit the lipolytic or ketogenic responses to epinephrine. Thus, the latter appear to be largely, perhaps exclusively, the result of direct actions of the hormone.

Original language	English
Title of host publication	Diabetes, obesity and hyperlipidemias-IV
Subtitle of host publication	proceedings of the 5th European Symposium on Metabolism. ICS872
Editors	G. Crepaldi, A. Tiengo, G. Enzi, G. Crepaldi, A. Tiengo, G. Enzi
Publisher	Elsevier Science Publishers B.V.
Pages	283-288
Number of pages	6
ISBN (Print)	0444811516
State	Published - Jan 1 1990
Event	The 5th European Symposium on Metabolism - Duration: May 15 1989 → May 17 1989

Publication series

Name	Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872

Conference

Conference	The 5th European Symposium on Metabolism
Period	05/15/89 → 05/17/89

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Cryer, P. E., Avogaro, A., & Bier, D. M. (1990). Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. In G. Crepaldi, A. Tiengo, G. Enzi, G. Crepaldi, A. Tiengo, & G. Enzi (Eds.), Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872 (pp. 283-288). (Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872). Elsevier Science Publishers B.V..

Cryer, P. E. ; Avogaro, A. ; Bier, D. M. / Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872. editor / G. Crepaldi ; A. Tiengo ; G. Enzi ; G. Crepaldi ; A. Tiengo ; G. Enzi. Elsevier Science Publishers B.V., 1990. pp. 283-288 (Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872).

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title = "Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans",

abstract = "There is substantial evidence to support the view that epinephrine is a biologically important hormone of the adrenal medullae in humans. The hyperglycemic effect of epinephrine involves both direct and indirect actions, the latter including limitation of insulin secretion. However, increased insulin secretion, albeit restrained, occurs during sustained hyperepinephrinemia and limits the magnitude of glycemic response. In sharp contrast, increased insulin secretion does not limit the lipolytic or ketogenic responses to epinephrine. Thus, the latter appear to be largely, perhaps exclusively, the result of direct actions of the hormone.",

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year = "1990",

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series = "Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872",

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editor = "G. Crepaldi and A. Tiengo and G. Enzi and G. Crepaldi and A. Tiengo and G. Enzi",

booktitle = "Diabetes, obesity and hyperlipidemias-IV",

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Cryer, PE, Avogaro, A & Bier, DM 1990, Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. in G Crepaldi, A Tiengo, G Enzi, G Crepaldi, A Tiengo & G Enzi (eds), Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872. Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872, Elsevier Science Publishers B.V., pp. 283-288, The 5th European Symposium on Metabolism, 05/15/89.

Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. / Cryer, P. E.; Avogaro, A.; Bier, D. M.

Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872. ed. / G. Crepaldi; A. Tiengo; G. Enzi; G. Crepaldi; A. Tiengo; G. Enzi. Elsevier Science Publishers B.V., 1990. p. 283-288 (Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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N2 - There is substantial evidence to support the view that epinephrine is a biologically important hormone of the adrenal medullae in humans. The hyperglycemic effect of epinephrine involves both direct and indirect actions, the latter including limitation of insulin secretion. However, increased insulin secretion, albeit restrained, occurs during sustained hyperepinephrinemia and limits the magnitude of glycemic response. In sharp contrast, increased insulin secretion does not limit the lipolytic or ketogenic responses to epinephrine. Thus, the latter appear to be largely, perhaps exclusively, the result of direct actions of the hormone.

AB - There is substantial evidence to support the view that epinephrine is a biologically important hormone of the adrenal medullae in humans. The hyperglycemic effect of epinephrine involves both direct and indirect actions, the latter including limitation of insulin secretion. However, increased insulin secretion, albeit restrained, occurs during sustained hyperepinephrinemia and limits the magnitude of glycemic response. In sharp contrast, increased insulin secretion does not limit the lipolytic or ketogenic responses to epinephrine. Thus, the latter appear to be largely, perhaps exclusively, the result of direct actions of the hormone.

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Cryer PE, Avogaro A, Bier DM. Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. In Crepaldi G, Tiengo A, Enzi G, Crepaldi G, Tiengo A, Enzi G, editors, Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872. Elsevier Science Publishers B.V. 1990. p. 283-288. (Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872).