Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans

P. E. Cryer, A. Avogaro, D. M. Bier

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

There is substantial evidence to support the view that epinephrine is a biologically important hormone of the adrenal medullae in humans. The hyperglycemic effect of epinephrine involves both direct and indirect actions, the latter including limitation of insulin secretion. However, increased insulin secretion, albeit restrained, occurs during sustained hyperepinephrinemia and limits the magnitude of glycemic response. In sharp contrast, increased insulin secretion does not limit the lipolytic or ketogenic responses to epinephrine. Thus, the latter appear to be largely, perhaps exclusively, the result of direct actions of the hormone.

Original languageEnglish
Title of host publicationDiabetes, obesity and hyperlipidemias-IV
Subtitle of host publicationproceedings of the 5th European Symposium on Metabolism. ICS872
EditorsG. Crepaldi, A. Tiengo, G. Enzi, G. Crepaldi, A. Tiengo, G. Enzi
PublisherElsevier Science Publishers B.V.
Pages283-288
Number of pages6
ISBN (Print)0444811516
StatePublished - Jan 1 1990
EventThe 5th European Symposium on Metabolism -
Duration: May 15 1989May 17 1989

Publication series

NameDiabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872

Conference

ConferenceThe 5th European Symposium on Metabolism
Period05/15/8905/17/89

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  • Cite this

    Cryer, P. E., Avogaro, A., & Bier, D. M. (1990). Interplay of epinephrine and insulin in the regulation of fatty acid and glucose flux in humans. In G. Crepaldi, A. Tiengo, G. Enzi, G. Crepaldi, A. Tiengo, & G. Enzi (Eds.), Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872 (pp. 283-288). (Diabetes, obesity and hyperlipidemias-IV: proceedings of the 5th European Symposium on Metabolism. ICS872). Elsevier Science Publishers B.V..