TY - JOUR
T1 - Intermittent Hiatus Hernia on High-Resolution Manometry Associates With Abnormal Reflux Burden Similar to Persistent Hiatus Hernia
AU - Luther, Janki
AU - Zarro, Samantha
AU - Sagaram, Manasa
AU - Eiswerth, Michael
AU - Ganguli, Surosree
AU - Rogers, Benjamin
AU - Prakash Gyawali, C.
N1 - Publisher Copyright:
© 2023 by The American College of Gastroenterology.
PY - 2023/11/1
Y1 - 2023/11/1
N2 - INTRODUCTION: Hiatus hernia is characterized by axial separation between the lower esophageal sphincter and the crural diaphragm, and higher reflux burden. Impact on reflux is unclear if such separation is intermittent rather than persistent. METHODS: Reflux burden off antisecretory therapy was compared between no hernia (n 5 357), intermittent hernia (n 5 42), and persistent hernia (n 5 155) after review of consecutive high-resolution manometry and reflux monitoring studies. RESULTS: Proportions with pathologic acid exposure was similar between intermittent and persistent hernia (45.2% vs 46.5%, respectively), and both were significantly different from no hernia (28.7%, P £ 0.002). DISCUSSION: Intermittent hiatus hernias are clinically relevant in gastroesophageal reflux pathophysiology.
AB - INTRODUCTION: Hiatus hernia is characterized by axial separation between the lower esophageal sphincter and the crural diaphragm, and higher reflux burden. Impact on reflux is unclear if such separation is intermittent rather than persistent. METHODS: Reflux burden off antisecretory therapy was compared between no hernia (n 5 357), intermittent hernia (n 5 42), and persistent hernia (n 5 155) after review of consecutive high-resolution manometry and reflux monitoring studies. RESULTS: Proportions with pathologic acid exposure was similar between intermittent and persistent hernia (45.2% vs 46.5%, respectively), and both were significantly different from no hernia (28.7%, P £ 0.002). DISCUSSION: Intermittent hiatus hernias are clinically relevant in gastroesophageal reflux pathophysiology.
KW - ambulatory reflux monitoring
KW - high-resolution manometry
KW - intermittent hernia
UR - http://www.scopus.com/inward/record.url?scp=85171721774&partnerID=8YFLogxK
U2 - 10.14309/ajg.0000000000002353
DO - 10.14309/ajg.0000000000002353
M3 - Article
C2 - 37307572
AN - SCOPUS:85171721774
SN - 0002-9270
VL - 118
SP - 2071
EP - 2074
JO - American Journal of Gastroenterology
JF - American Journal of Gastroenterology
IS - 11
ER -