Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Larry D. Spears; Babak Razani; Clay F. Semenkovich

doi:10.1016/j.cmet.2013.10.009

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Larry D. Spears, Babak Razani, Clay F. Semenkovich

Research output: Contribution to journal › Short survey › peer-review

12 Scopus citations

Abstract

Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.

Original language	English
Pages (from-to)	614-616
Number of pages	3
Journal	Cell metabolism
Volume	18
Issue number	5
DOIs	https://doi.org/10.1016/j.cmet.2013.10.009
State	Published - Nov 5 2013

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title = "Interleukins and Atherosclerosis: A Dysfunctional Family Grows",

abstract = "Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.",

author = "Spears, {Larry D.} and Babak Razani and Semenkovich, {Clay F.}",

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year = "2013",

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T2 - A Dysfunctional Family Grows

AU - Spears, Larry D.

AU - Razani, Babak

AU - Semenkovich, Clay F.

PY - 2013/11/5

Y1 - 2013/11/5

N2 - Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.

AB - Atherosclerosis is driven by the release of cytokines from macrophages, and the β isoform of interleukin-1 (IL-1β) is a prime suspect in disease progression. Freigang et al. (2013) now suggest that IL-1α, a close relative, is selectively induced by fatty acids independent of the inflammasome to promote vascular inflammation.

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U2 - 10.1016/j.cmet.2013.10.009

DO - 10.1016/j.cmet.2013.10.009

M3 - Short survey

C2 - 24206661

AN - SCOPUS:84901873686

SN - 1550-4131

VL - 18

SP - 614

EP - 616

JO - Cell metabolism

JF - Cell metabolism

IS - 5

ER -

Interleukins and Atherosclerosis: A Dysfunctional Family Grows

Abstract

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