TY - JOUR
T1 - Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation
AU - Takagi, Miki
AU - Egawa, Takeshi
AU - Motomura, Takashi
AU - Sakuma-Mochizuki, Junko
AU - Nishimoto, Norihiro
AU - Kasayama, Soji
AU - Hayashi, Seiji
AU - Koga, Masafumi
AU - Yoshizaki, Kazuyuki
AU - Yoshioka, Toshiaki
AU - Okuyama, Akihiko
AU - Kishimoto, Tadamitsu
PY - 1997
Y1 - 1997
N2 - Phaeochromocytomas have been shown to produce not only catecholamines but other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70-year-old female patient with phaeochromocytoma exhibiting sustained hypertension, low-grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C-reactive protein. Serum interleukin (IL)-6 levels were significantly elevated, whereas serum IL-1α and L-1β were not detectable. After surgical removal of the tumour, hypertension and low-grade fever disappeared, and the laboratory findings including serum IL-6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL-6. Culture of the resected tumour revealed the production of large amounts of IL-6. It is suggested that IL-6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.
AB - Phaeochromocytomas have been shown to produce not only catecholamines but other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70-year-old female patient with phaeochromocytoma exhibiting sustained hypertension, low-grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C-reactive protein. Serum interleukin (IL)-6 levels were significantly elevated, whereas serum IL-1α and L-1β were not detectable. After surgical removal of the tumour, hypertension and low-grade fever disappeared, and the laboratory findings including serum IL-6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL-6. Culture of the resected tumour revealed the production of large amounts of IL-6. It is suggested that IL-6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.
UR - http://www.scopus.com/inward/record.url?scp=8244250133&partnerID=8YFLogxK
U2 - 10.1046/j.1365-2265.1997.1160931.x
DO - 10.1046/j.1365-2265.1997.1160931.x
M3 - Article
C2 - 9196615
AN - SCOPUS:8244250133
VL - 46
SP - 507
EP - 509
JO - Clinical Endocrinology
JF - Clinical Endocrinology
SN - 0300-0664
IS - 4
ER -