Interleukin-6 secreting phaeochromocytoma associated with clinical markers of inflammation

Miki Takagi, Takeshi Egawa, Takashi Motomura, Junko Sakuma-Mochizuki, Norihiro Nishimoto, Soji Kasayama, Seiji Hayashi, Masafumi Koga, Kazuyuki Yoshizaki, Toshiaki Yoshioka, Akihiko Okuyama, Tadamitsu Kishimoto

Research output: Contribution to journalArticlepeer-review

35 Scopus citations


Phaeochromocytomas have been shown to produce not only catecholamines but other neuropeptides and hormones, with a variety of clinical manifestations. We report a 70-year-old female patient with phaeochromocytoma exhibiting sustained hypertension, low-grade fever, thrombocytosis, and elevated levels of plasma fibrinogen and C-reactive protein. Serum interleukin (IL)-6 levels were significantly elevated, whereas serum IL-1α and L-1β were not detectable. After surgical removal of the tumour, hypertension and low-grade fever disappeared, and the laboratory findings including serum IL-6 concentrations became normal. Immunohistochemical study of the tumour showed positive staining for IL-6. Culture of the resected tumour revealed the production of large amounts of IL-6. It is suggested that IL-6 secreted by the tumour was responsible for some of the clinical manifestations in this patient.

Original languageEnglish
Pages (from-to)507-509
Number of pages3
JournalClinical Endocrinology
Issue number4
StatePublished - 1997


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