TY - JOUR
T1 - Interleukin-36 Cytokines in Infectious and Non-Infectious Lung Diseases
AU - Peñaloza, Hernán F.
AU - van der Geest, Rick
AU - Ybe, Joel A.
AU - Standiford, Theodore J.
AU - Lee, Janet S.
N1 - Funding Information:
This work was supported in part by the University of Pittsburgh Vascular Medicine Institute, the Hemophilia Center of Western Pennsylvania, and the Institute for Transfusion Medicine (HP), the National Heart, Lung, And Blood Institute of the National Institutes of Health under Award Numbers; P01 HL114453, R01 HL136143, R01 HL142084, K24 HL143285 (JL), R01 HL123515 (TS).
Publisher Copyright:
Copyright © 2021 Peñaloza, van der Geest, Ybe, Standiford and Lee.
PY - 2021/11/23
Y1 - 2021/11/23
N2 - The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
AB - The IL-36 family of cytokines were identified in the early 2000’s as a new subfamily of the IL-1 cytokine family, and since then, the role of IL-36 cytokines during various inflammatory processes has been characterized. While most of the research has focused on the role of these cytokines in autoimmune skin diseases such as psoriasis and dermatitis, recent studies have also shown the importance of IL-36 cytokines in the lung inflammatory response during infectious and non-infectious diseases. In this review, we discuss the biology of IL-36 cytokines in terms of how they are produced and activated, as well as their effects on myeloid and lymphoid cells during inflammation. We also discuss the role of these cytokines during lung infectious diseases caused by bacteria and influenza virus, as well as other inflammatory conditions in the lungs such as allergic asthma, lung fibrosis, chronic obstructive pulmonary disease, cystic fibrosis and cancer. Finally, we discuss the current therapeutic advances that target the IL-36 pathway and the possibility to extend these tools to treat lung inflammatory diseases.
KW - IL-1Rrp2
KW - host/microbe proteases
KW - inflammatory response amplification
KW - interleukin-36 cytokines
KW - lung infectious diseases
KW - lung inflammation
UR - http://www.scopus.com/inward/record.url?scp=85120873622&partnerID=8YFLogxK
U2 - 10.3389/fimmu.2021.754702
DO - 10.3389/fimmu.2021.754702
M3 - Review article
C2 - 34887860
AN - SCOPUS:85120873622
SN - 1664-3224
VL - 12
JO - Frontiers in immunology
JF - Frontiers in immunology
M1 - 754702
ER -