Interleukin-22 signaling in the regulation of intestinal health and disease

Olivia B. Parks, Derek A. Pociask, Zerina Hodzic, Jay K. Kolls, Misty Good

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations


Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.

Original languageEnglish
Article number85
JournalFrontiers in Cell and Developmental Biology
Issue numberJAN
StatePublished - Jan 13 2016


  • Barrier defense
  • Epithelial cells
  • Gastrointestinal tract
  • Interleukin-22


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