Interleukin-22 signaling in the regulation of intestinal health and disease

Olivia B. Parks; Derek A. Pociask; Zerina Hodzic; Jay K. Kolls; Misty Good

doi:10.3389/fcell.2015.00085

Interleukin-22 signaling in the regulation of intestinal health and disease

Olivia B. Parks, Derek A. Pociask, Zerina Hodzic, Jay K. Kolls, Misty Good

Research output: Contribution to journal › Review article › peer-review

144 Scopus citations

Abstract

Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.

Original language	English
Article number	85
Journal	Frontiers in Cell and Developmental Biology
Volume	3
Issue number	JAN
DOIs	https://doi.org/10.3389/fcell.2015.00085
State	Published - Jan 13 2016

Keywords

Barrier defense
Epithelial cells
Gastrointestinal tract
Interleukin-22

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title = "Interleukin-22 signaling in the regulation of intestinal health and disease",

abstract = "Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.",

keywords = "Barrier defense, Epithelial cells, Gastrointestinal tract, Interleukin-22",

author = "Parks, {Olivia B.} and Pociask, {Derek A.} and Zerina Hodzic and Kolls, {Jay K.} and Misty Good",

note = "Publisher Copyright: {\textcopyright} 2016 Parks, Pociask, Hodzic, Kolls and Good.",

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AU - Parks, Olivia B.

AU - Pociask, Derek A.

AU - Hodzic, Zerina

AU - Kolls, Jay K.

AU - Good, Misty

PY - 2016/1/13

Y1 - 2016/1/13

N2 - Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.

AB - Interleukin (IL)-22 is a member of the IL-10 family of cytokines that has been extensively studied since its discovery in 2000. This review article aims to describe the cellular sources and signaling pathways of this cytokine as well as the functions of IL-22 in the intestine. In addition, this article describes the roles of IL-22 in the pathogenesis of several gastrointestinal diseases, including inhibition of inflammation and barrier defense against pathogens within the intestine. Since many of the functions of IL-22 in the intestine are incompletely understood, this review is meant to assess our current understanding of the roles of IL-22 and provide new opportunities for inquiry to improve human intestinal health and disease.

KW - Barrier defense

KW - Epithelial cells

KW - Gastrointestinal tract

KW - Interleukin-22

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JO - Frontiers in Cell and Developmental Biology

JF - Frontiers in Cell and Developmental Biology

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Interleukin-22 signaling in the regulation of intestinal health and disease

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Keywords

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