Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis

Li Hao Huang, Bernd H. Zinselmeyer, Chih Hao Chang, Brian T. Saunders, Andrew Elvington, Osamu Baba, Thomas J. Broekelmann, Lina Qi, Joseph S. Rueve, Melody A. Swartz, Brian S. Kim, Robert P. Mecham, Helge Wiig, Michael J. Thomas, Mary G. Sorci-Thomas, Gwendalyn J. Randolph

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

HDL removes tissue cholesterol and recirculates to the plasma. Huang et al. generated a photoactivatable HDL tracking tool that they applied to psoriasis, which has been clinically linked to cardiovascular comorbidity. They find that Th17 autoimmunity promotes collagen deposition in skin and arteries, thus entrapping HDL and LDL to drive cardiovascular risk.

Original languageEnglish
Pages (from-to)475-487.e7
JournalCell metabolism
Volume29
Issue number2
DOIs
StatePublished - Feb 5 2019

Keywords

  • Th17 immunity
  • artery
  • atherosclerosis
  • autoimmunity
  • collagen
  • cytokines
  • extracellular matrix
  • fibrosis
  • interstitial transport
  • skin

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