HDL removes tissue cholesterol and recirculates to the plasma. Huang et al. generated a photoactivatable HDL tracking tool that they applied to psoriasis, which has been clinically linked to cardiovascular comorbidity. They find that Th17 autoimmunity promotes collagen deposition in skin and arteries, thus entrapping HDL and LDL to drive cardiovascular risk.

Original languageEnglish
Pages (from-to)475-487.e7
JournalCell metabolism
Issue number2
StatePublished - Feb 5 2019


  • Th17 immunity
  • artery
  • atherosclerosis
  • autoimmunity
  • collagen
  • cytokines
  • extracellular matrix
  • fibrosis
  • interstitial transport
  • skin


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