@article{d5f83bb927cd45b1b61012faaffa882b,
title = "Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis",
abstract = "HDL removes tissue cholesterol and recirculates to the plasma. Huang et al. generated a photoactivatable HDL tracking tool that they applied to psoriasis, which has been clinically linked to cardiovascular comorbidity. They find that Th17 autoimmunity promotes collagen deposition in skin and arteries, thus entrapping HDL and LDL to drive cardiovascular risk.",
keywords = "Th17 immunity, artery, atherosclerosis, autoimmunity, collagen, cytokines, extracellular matrix, fibrosis, interstitial transport, skin",
author = "Huang, {Li Hao} and Zinselmeyer, {Bernd H.} and Chang, {Chih Hao} and Saunders, {Brian T.} and Andrew Elvington and Osamu Baba and Broekelmann, {Thomas J.} and Lina Qi and Rueve, {Joseph S.} and Swartz, {Melody A.} and Kim, {Brian S.} and Mecham, {Robert P.} and Helge Wiig and Thomas, {Michael J.} and Sorci-Thomas, {Mary G.} and Randolph, {Gwendalyn J.}",
note = "Funding Information: This work was supported by NIH grants R01 HL118206 and DP1DK109668 (to G.J.R.). Salary support for L.H. was supplied by The Leading Technology Group (to G.J.R.), 4 T32 AI 7163-39 (Washington University, Division of Immunology), and a Career Development Award from AHA (to L.H.). Additional support was supplied by NIH grants R01HL112276 and R01HL127649 (to M.G.S.-T.), American Heart Association 14GRNT20500029 (to M.J.T.), 16SDGG30480008 (to B.H.Z.), and R37AI496653 (to G.J.R.). We are grateful to Mary Wohltmann and Shashi Bala for assistance in the laboratory, to Merry Lindsey for advice and protocols, and to the Genome Engineering and iPSC Center and Mike White in the Pathology Microinjection Core at Washington University for their help in generating the PGA1 mouse line, to Washington University Center for Cellular Imaging (WUCCI) for focused ion beam electron microscopy, and the Mass Spectrometry Facility for Proteomics at Medical College of Wisconsin for mass spectrometry. Funding Information: This work was supported by NIH grants R01 HL118206 and DP1DK109668 (to G.J.R.). Salary support for L.H. was supplied by The Leading Technology Group (to G.J.R.), 4 T32 AI 7163-39 (Washington University, Division of Immunology), and a Career Development Award from AHA (to L.H.). Additional support was supplied by NIH grants R01HL112276 and R01HL127649 (to M.G.S.-T.), American Heart Association 14GRNT20500029 (to M.J.T.), 16SDGG30480008 (to B.H.Z.), and R37AI496653 (to G.J.R.). We are grateful to Mary Wohltmann and Shashi Bala for assistance in the laboratory, to Merry Lindsey for advice and protocols, and to the Genome Engineering and iPSC Center and Mike White in the Pathology Microinjection Core at Washington University for their help in generating the PGA1 mouse line, to Washington University Center for Cellular Imaging (WUCCI) for focused ion beam electron microscopy, and the Mass Spectrometry Facility for Proteomics at Medical College of Wisconsin for mass spectrometry. Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = feb,
day = "5",
doi = "10.1016/j.cmet.2018.10.006",
language = "English",
volume = "29",
pages = "475--487.e7",
journal = "Cell Metabolism",
issn = "1550-4131",
number = "2",
}