Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection

Shabaana A. Khader, Santiago Partida-Sanchez, Guy Bell, Dawn M. Jelley-Gibbs, Susan Swain, John E. Pearl, Nico Ghilardi, Frederic J. DeSauvage, Frances E. Lund, Andrea M. Cooper

Research output: Contribution to journalArticle

218 Scopus citations

Abstract

Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40-deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40-deficient DCs with IL-12p40 homodimer (IL-12(p40)2) restores Mtb-induced DC migration and the ability of IL-12p40-deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogeninduced activation of pulmonary DCs. JEM

Original languageEnglish
Pages (from-to)1805-1815
Number of pages11
JournalJournal of Experimental Medicine
Volume203
Issue number7
DOIs
StatePublished - Jul 10 2006
Externally publishedYes

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    Khader, S. A., Partida-Sanchez, S., Bell, G., Jelley-Gibbs, D. M., Swain, S., Pearl, J. E., Ghilardi, N., DeSauvage, F. J., Lund, F. E., & Cooper, A. M. (2006). Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection. Journal of Experimental Medicine, 203(7), 1805-1815. https://doi.org/10.1084/jem.20052545