TY - JOUR
T1 - Interleukin-12 and tuberculosis
T2 - an old story revisited
AU - Cooper, Andrea M.
AU - Solache, Alejandra
AU - Khader, Shabaana A.
N1 - Funding Information:
This work was supported by the Trudeau Institute, Inc.; a New York Community Trust-Heiser Fund Fellowship to SAK and National Institutes of Health grants AI46530, AI067723, AG028878 to AMC.
PY - 2007/8
Y1 - 2007/8
N2 - Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.
AB - Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.
UR - http://www.scopus.com/inward/record.url?scp=34548008127&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2007.07.004
DO - 10.1016/j.coi.2007.07.004
M3 - Review article
C2 - 17702558
AN - SCOPUS:34548008127
SN - 0952-7915
VL - 19
SP - 441
EP - 447
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 4
ER -