Interleukin-1β activates PI 3-kinase in renal mesangial cells

Audrey Donaldson, Dorit Daphna-Iken, Toshifumi Tetsuka, Aubrey R. Morrison

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Interleukin-1β rapidly stimulates the activation of phosphatidylinositol 3-hydroxyl kinase in renal mesangial cells. This interleukin-1β dependent activation is associated with a rapid increase in phosphatidyl inositol 3,4,5 phosphate in renal mesangial cells. The increase in PI 3-kinase activity is inhibited by wortmannin. In addition wortmannin partially inhibited IL-1β induced PGE2 production and potentiated IL-1β induced nitric oxide production. These experiments suggest that IL-1β can activate PI 3-kinase in renal mesangial cells and that the enzyme plays a role in IL-1β induced PGE2 and NO formation in the renal mesangial cell.

Original languageEnglish
Pages (from-to)289-293
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number1
StatePublished - Oct 3 1996


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