TY - JOUR
T1 - Interlaced photoacoustic and ultrasound imaging system with real-time coregistration for ovarian tissue characterization
AU - Alqasemi, Umar
AU - Li, Hai
AU - Yuan, Guangqian
AU - Kumavor, Patrick
AU - Zanganeh, Saeid
AU - Zhu, Quing
PY - 2014/7
Y1 - 2014/7
N2 - Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.
AB - Coregistered ultrasound (US) and photoacoustic imaging are emerging techniques for mapping the echogenic anatomical structure of tissue and its corresponding optical absorption. We report a 128-channel imaging system with real-time coregistration of the two modalities, which provides up to 15 coregistered frames per second limited by the laser pulse repetition rate. In addition, the system integrates a compact transvaginal imaging probe with a custom-designed fiber optic assembly for in vivo detection and characterization of human ovarian tissue. We present the coregistered US and photoacoustic imaging system structure, the optimal design of the PC interfacing software, and the reconfigurable field programmable gate array operation and optimization. Phantom experiments of system lateral resolution and axial sensitivity evaluation, examples of the real-time scanning of a tumor-bearing mouse, and ex vivo human ovaries studies are demonstrated.
KW - coregistered ultrasound and photoacoustic imaging
KW - field programmable gate array
KW - ovarian cancer
KW - peripheral component interconnect express interfacing
KW - reconfigurable computing
UR - https://www.scopus.com/pages/publications/84924456028
U2 - 10.1117/1.JBO.19.7.076020
DO - 10.1117/1.JBO.19.7.076020
M3 - Article
C2 - 25069009
AN - SCOPUS:84924456028
SN - 1083-3668
VL - 19
JO - Journal of biomedical optics
JF - Journal of biomedical optics
IS - 7
M1 - 076020
ER -