Interim analysis of the use of the anti-idiotype breast cancer vaccine 11D10 (TriAb®) in conjunction with autologous stem cell transplantation in patients with metastatic breast cancer

Donna E. Reece, Kenneth A. Foon, Malaya Battacharya-Chatterjee, Doug Adkins, E. Randolph Broun, D. Gerald Connaghan, John F. Dipersio, H. Kent Holland, Dianna S. Howard, Greg A. Hale, Hans G. Klingemann, Rita K. Munn, Anastasios Raptis, Gordon L. Phillips

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8 Scopus citations

Abstract

The anti-idiotype monoclonal antibody breast cancer vaccine 11D10 (TriAb®) was administered before and after autologous stem cell transplantation (ASCT) in 45 patients with metastatic breast cancer whose disease was responsive to conventional chemotherapy. Evidence of a positive anti-anti-idiotype antibody (Ab3) humoral response was noted at a median of 1.75 months post-ASCT (range, before ASCT-6 months) with this strategy. Maximal Ab3 levels and idiotype-specific T-cell proliferative responses were observed at a median of 3 and 4 months, respectively, after ASCT. The achievement of rapid immune responses after ASCT, during a known period of decreased immunoresponsiveness, opens the possibility of an additional antitumor effect at a time when the tumor burden is relatively small. Moreover, in this interim analysis, patients with the most vigorous humoral and cellular immune responses had a significant improvement in progression-free survival. Further follow-up and evaluation of this approach is warranted.

Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalClinical breast cancer
Volume2
Issue number1
DOIs
StatePublished - Apr 2001

Keywords

  • Autotransplantation
  • Human milk fat globule
  • T-cell proliferative response
  • TriAb breast cancer vaccine

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    Reece, D. E., Foon, K. A., Battacharya-Chatterjee, M., Adkins, D., Broun, E. R., Connaghan, D. G., Dipersio, J. F., Holland, H. K., Howard, D. S., Hale, G. A., Klingemann, H. G., Munn, R. K., Raptis, A., & Phillips, G. L. (2001). Interim analysis of the use of the anti-idiotype breast cancer vaccine 11D10 (TriAb®) in conjunction with autologous stem cell transplantation in patients with metastatic breast cancer. Clinical breast cancer, 2(1), 52-58. https://doi.org/10.3816/CBC.2001.n.011