TY - JOUR
T1 - Interferons, immunity and cancer immunoediting
AU - Dunn, Gavin P.
AU - Koebel, Catherine M.
AU - Schreiber, Robert D.
N1 - Funding Information:
The authors are grateful to the following individuals: L. J. Old and M. J. Smyth for past and continuing collaborations and for critical comment during the preparation of this Review; G. P. Linette for helpful comment on the clinical use of IFNs in cancer immunotherapy; and all past and present members of the Schreiber laboratory for their essential contributions to the development of the cancer-immunoediting hypothesis. This work was supported by grants from the National Cancer Institute (United States), the Ludwig Institute for Cancer Research (United States) and the Cancer Research Institute (United States).
PY - 2006/11/13
Y1 - 2006/11/13
N2 - A clear picture of the dynamic relationship between the host immune system and cancer is emerging as the cells and molecules that participate in naturally occurring antitumour immune responses are being identified. The interferons (IFNs) - that is, the type I IFNs (IFNα and IFNβ) and type II IFN (IFNγ) - have emerged as central coordinators of tumour-immune-system interactions. Indeed, the decade-old finding that IFNγ has a pivotal role in promoting antitumour responses became the focus for a renewed interest in the largely abandoned concept of cancer immunosurveillance. More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
AB - A clear picture of the dynamic relationship between the host immune system and cancer is emerging as the cells and molecules that participate in naturally occurring antitumour immune responses are being identified. The interferons (IFNs) - that is, the type I IFNs (IFNα and IFNβ) and type II IFN (IFNγ) - have emerged as central coordinators of tumour-immune-system interactions. Indeed, the decade-old finding that IFNγ has a pivotal role in promoting antitumour responses became the focus for a renewed interest in the largely abandoned concept of cancer immunosurveillance. More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.
UR - http://www.scopus.com/inward/record.url?scp=33750321707&partnerID=8YFLogxK
U2 - 10.1038/nri1961
DO - 10.1038/nri1961
M3 - Review article
C2 - 17063185
AN - SCOPUS:33750321707
SN - 1474-1733
VL - 6
SP - 836
EP - 848
JO - Nature Reviews Immunology
JF - Nature Reviews Immunology
IS - 11
ER -