Interferons, immunity and cancer immunoediting

Gavin P. Dunn, Catherine M. Koebel, Robert D. Schreiber

Research output: Contribution to journalReview article

973 Scopus citations

Abstract

A clear picture of the dynamic relationship between the host immune system and cancer is emerging as the cells and molecules that participate in naturally occurring antitumour immune responses are being identified. The interferons (IFNs) - that is, the type I IFNs (IFNα and IFNβ) and type II IFN (IFNγ) - have emerged as central coordinators of tumour-immune-system interactions. Indeed, the decade-old finding that IFNγ has a pivotal role in promoting antitumour responses became the focus for a renewed interest in the largely abandoned concept of cancer immunosurveillance. More recently, type I IFNs have been found to have distinct functions in this process. In this Review, we discuss the roles of the IFNs, not only in cancer immunosurveillance but also in the broader process of cancer immunoediting.

Original languageEnglish
Pages (from-to)836-848
Number of pages13
JournalNature Reviews Immunology
Volume6
Issue number11
DOIs
StatePublished - Nov 13 2006

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