Interferon-producing cells: On the front line in immune responses against pathogens

Research output: Contribution to journalReview article

198 Scopus citations

Abstract

Interferon-producing cells (IPC) constitute a small population of leukocytes that secrete high levels of type I interferons in response to viruses. Although human IPC have been known for almost two decades, murine IPC have been identified only recently. Furthermore, it has been shown that IPC correspond to the enigmatic 'plasmacytoid cells' identified in human lymph nodes during infections. These breakthroughs have brought IPC to the attention of immunologists for their role in innate immunity and in shaping T cell responses. Here we review recent progress and outstanding questions in the field.

Original languageEnglish
Pages (from-to)373-379
Number of pages7
JournalCurrent Opinion in Immunology
Volume14
Issue number3
DOIs
StatePublished - Jun 1 2002

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