Interferon as an Inhibitor of Cell Growth: Studies with Mouse Melanoma Cells

Lee Ratner, James J. Nordlund, Peter Lengyel

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Interferon treatment was found to inhibit the growth of Cloudman mouse melanoma cells in tissue culture. This was not associated with a block in the G2 or M phases of the cell cycle. A highly purified interferon preparation, approximately 30% pure, was as effective as a less purified interferon preparation, less than 1% pure, in inhibiting melanoma cell growth. This suggests that interferon rather than contaminants in the preparation is responsible for the effects seen. The growth of the melanoma cells in DBA/2 mice was also retarded upon interferon treatment.

Original languageEnglish
Pages (from-to)267-272
Number of pages6
JournalProceedings of the Society for Experimental Biology and Medicine
Volume163
Issue number2
DOIs
StatePublished - Feb 1980

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