TY - JOUR
T1 - Interferon as an Inhibitor of Cell Growth
T2 - Studies with Mouse Melanoma Cells
AU - Ratner, Lee
AU - Nordlund, James J.
AU - Lengyel, Peter
PY - 1980/2
Y1 - 1980/2
N2 - Interferon treatment was found to inhibit the growth of Cloudman mouse melanoma cells in tissue culture. This was not associated with a block in the G2 or M phases of the cell cycle. A highly purified interferon preparation, approximately 30% pure, was as effective as a less purified interferon preparation, less than 1% pure, in inhibiting melanoma cell growth. This suggests that interferon rather than contaminants in the preparation is responsible for the effects seen. The growth of the melanoma cells in DBA/2 mice was also retarded upon interferon treatment.
AB - Interferon treatment was found to inhibit the growth of Cloudman mouse melanoma cells in tissue culture. This was not associated with a block in the G2 or M phases of the cell cycle. A highly purified interferon preparation, approximately 30% pure, was as effective as a less purified interferon preparation, less than 1% pure, in inhibiting melanoma cell growth. This suggests that interferon rather than contaminants in the preparation is responsible for the effects seen. The growth of the melanoma cells in DBA/2 mice was also retarded upon interferon treatment.
UR - http://www.scopus.com/inward/record.url?scp=0018887474&partnerID=8YFLogxK
U2 - 10.3181/00379727-163-40760
DO - 10.3181/00379727-163-40760
M3 - Article
C2 - 7360756
AN - SCOPUS:0018887474
SN - 0037-9727
VL - 163
SP - 267
EP - 272
JO - Proceedings of the Society for Experimental Biology and Medicine
JF - Proceedings of the Society for Experimental Biology and Medicine
IS - 2
ER -