TY - JOUR
T1 - Interferon-λ
T2 - Immune Functions at Barrier Surfaces and Beyond
AU - Lazear, Helen M.
AU - Nice, Timothy J.
AU - Diamond, Michael S.
N1 - Funding Information:
This work was supported by NIH grants U19 AI083019 and R01 AI074973 (M.S.D). T.J.N. was supported by NIH training grant 5T32A100716334 and postdoctoral fellowships from the Cancer Research Institute and American Cancer Society.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/7/21
Y1 - 2015/7/21
N2 - When type III interferon (IFN-λ) also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially in cells of epithelial origin, recent studies have defined additional antiviral mechanisms in other cell types and tissues. Viral infection models using mice lacking IFN-λ signaling and SNP associations with human disease have expanded our understanding of the contribution of IFN-λ to the antiviral response at anatomic barriers and the immune response beyond these barriers. In this review, we highlight recent insights into IFN-λ functions, including its ability to restrict virus spread into the brain and to clear chronic viral infections in the gastrointestinal tract. We also discuss how IFN-λ modulates innate and adaptive immunity, autoimmunity, and tumor progression and its possible therapeutic applications in human disease.
AB - When type III interferon (IFN-λ) also known as interleukin-28 [IL-28] and IL-29) was discovered in 2003, its antiviral function was expected to be analogous to that of type I IFNs (IFN-α and IFN-β) via the induction of IFN-stimulated genes (ISGs). Although IFN-λ stimulates expression of antiviral ISGs preferentially in cells of epithelial origin, recent studies have defined additional antiviral mechanisms in other cell types and tissues. Viral infection models using mice lacking IFN-λ signaling and SNP associations with human disease have expanded our understanding of the contribution of IFN-λ to the antiviral response at anatomic barriers and the immune response beyond these barriers. In this review, we highlight recent insights into IFN-λ functions, including its ability to restrict virus spread into the brain and to clear chronic viral infections in the gastrointestinal tract. We also discuss how IFN-λ modulates innate and adaptive immunity, autoimmunity, and tumor progression and its possible therapeutic applications in human disease.
UR - http://www.scopus.com/inward/record.url?scp=84937722616&partnerID=8YFLogxK
U2 - 10.1016/j.immuni.2015.07.001
DO - 10.1016/j.immuni.2015.07.001
M3 - Review article
C2 - 26200010
AN - SCOPUS:84937722616
SN - 1074-7613
VL - 43
SP - 15
EP - 28
JO - Immunity
JF - Immunity
IS - 1
ER -