Interferon-γ and chronic granulomatous disease

Mary C. Dinauer, R. Alan B. Ezekowitz

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

The molecular and biochemical characterization of many components of the phagocyte oxidase complex that generates superoxide have greatly advanced our understanding of this important pathway. Genetic defects in one or more of the components of this host defense system result in the chronic granulomatous disease phenotype. Biochemical advances and the results of a clinical trial that established the efficacy of recombinant human interferon-γ for prophylaxis of infections in chronic granulomatous disease are the highlights of recent achievements in this area of phagocyte biology.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalCurrent Opinion in Immunology
Volume3
Issue number1
DOIs
StatePublished - 1991
Externally publishedYes

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