121 Scopus citations

Abstract

Over the last 12 yr, we have shown that interferon-γ and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.

Original languageEnglish
Pages (from-to)231-245
Number of pages15
JournalImmunologic Research
Volume32
Issue number1-3
DOIs
StatePublished - 2005

Keywords

  • Cancer
  • Cancer immunoediting
  • Immunosurveillance
  • Interferon-γ
  • Lymphocytes
  • Signal transduction

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