Interferon-γ and cancer immunoediting

Gavin P. Dunn; Hiroaki Ikeda; Allen T. Bruce; Catherine Koebel; Ravi Uppaluri; Jack Bui; Ruby Chan; Mark Diamond; J. Michael White; Kathleen C.F. Sheehan; Robert D. Schreiber

doi:10.1385/IR:32:1-3:231

Interferon-γ and cancer immunoediting

Gavin P. Dunn, Hiroaki Ikeda, Allen T. Bruce, Catherine Koebel, Ravi Uppaluri, Jack Bui, Ruby Chan, Mark Diamond, J. Michael White, Kathleen C.F. Sheehan, Robert D. Schreiber

Research output: Contribution to journal › Review article › peer-review

125 Scopus citations

Abstract

Over the last 12 yr, we have shown that interferon-γ and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.

Original language	English
Pages (from-to)	231-245
Number of pages	15
Journal	Immunologic Research
Volume	32
Issue number	1-3
DOIs	https://doi.org/10.1385/IR:32:1-3:231
State	Published - 2005

Keywords

Cancer
Cancer immunoediting
Immunosurveillance
Interferon-γ
Lymphocytes
Signal transduction

Access to Document

10.1385/IR:32:1-3:231

Cite this

@article{204b8b2e789048dcbb65f4a174e5a720,

title = "Interferon-γ and cancer immunoediting",

abstract = "Over the last 12 yr, we have shown that interferon-γ and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial {"}cancer immunosurveillance{"} hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.",

keywords = "Cancer, Cancer immunoediting, Immunosurveillance, Interferon-γ, Lymphocytes, Signal transduction",

author = "Dunn, {Gavin P.} and Hiroaki Ikeda and Bruce, {Allen T.} and Catherine Koebel and Ravi Uppaluri and Jack Bui and Ruby Chan and Mark Diamond and White, {J. Michael} and Sheehan, {Kathleen C.F.} and Schreiber, {Robert D.}",

year = "2005",

doi = "10.1385/IR:32:1-3:231",

language = "English",

volume = "32",

pages = "231--245",

journal = "Immunologic Research",

issn = "0257-277X",

number = "1-3",

}

TY - JOUR

T1 - Interferon-γ and cancer immunoediting

AU - Dunn, Gavin P.

AU - Ikeda, Hiroaki

AU - Bruce, Allen T.

AU - Koebel, Catherine

AU - Uppaluri, Ravi

AU - Bui, Jack

AU - Chan, Ruby

AU - Diamond, Mark

AU - White, J. Michael

AU - Sheehan, Kathleen C.F.

AU - Schreiber, Robert D.

PY - 2005

Y1 - 2005

N2 - Over the last 12 yr, we have shown that interferon-γ and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.

AB - Over the last 12 yr, we have shown that interferon-γ and lymphocytes collaborate to regulate tumor development in mice. Specifically, we found that the immune system not only prevents the growth of primary (carcinogen-induced and spontaneous) and transplanted tumors but also sculpts the immunogenicity of tumors that form. These observations led us to refine the old and controversial "cancer immunosurveillance" hypothesis of Burnet and Thomas into one that we termed cancer immunoediting that better emphasizes the paradoxical host-protective and tumor-sculpting roles of immunity on developing tumors. Our current work focuses on defining the molecular mechanisms that underlie cancer immunoediting and exploring the implications of this process for cancer immunotherapy.

KW - Cancer

KW - Cancer immunoediting

KW - Immunosurveillance

KW - Interferon-γ

KW - Lymphocytes

KW - Signal transduction

UR - http://www.scopus.com/inward/record.url?scp=23844446653&partnerID=8YFLogxK

U2 - 10.1385/IR:32:1-3:231

DO - 10.1385/IR:32:1-3:231

M3 - Review article

C2 - 16106075

AN - SCOPUS:23844446653

SN - 0257-277X

VL - 32

SP - 231

EP - 245

JO - Immunologic Research

JF - Immunologic Research

IS - 1-3

ER -

Interferon-γ and cancer immunoediting

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this