@article{180a116402f146458fde0eb0bd71b403,
title = "Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity",
abstract = "Brestoff et al. show that adipose-tissue-resident macrophages acquire mitochondria from neighboring adipocytes in a heparan-sulfate-dependent process that is impaired in obesity. Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.",
keywords = "beige adipose tissue, brown adipose tissue, horizontal mitochondria transfer, immunometabolism, intercellular mitochondria transfer, macrophage, metabolism, mitochondria, obesity, white adipose tissue",
author = "Brestoff, \{Jonathan R.\} and Wilen, \{Craig B.\} and Moley, \{John R.\} and Yongjia Li and Wei Zou and Malvin, \{Nicole P.\} and Rowen, \{Marina N.\} and Saunders, \{Brian T.\} and Hongming Ma and Mack, \{Madison R.\} and Hykes, \{Barry L.\} and Balce, \{Dale R.\} and Anthony Orvedahl and Williams, \{Jesse W.\} and Nidhi Rohatgi and Xiaoyan Wang and McAllaster, \{Michael R.\} and Handley, \{Scott A.\} and Kim, \{Brian S.\} and Doench, \{John G.\} and Zinselmeyer, \{Bernd H.\} and Diamond, \{Michael S.\} and Virgin, \{Herbert W.\} and Gelman, \{Andrew E.\} and Teitelbaum, \{Steven L.\}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",
year = "2021",
month = feb,
day = "2",
doi = "10.1016/j.cmet.2020.11.008",
language = "English",
volume = "33",
pages = "270--282.e8",
journal = "Cell metabolism",
issn = "1550-4131",
number = "2",
}