@article{180a116402f146458fde0eb0bd71b403,
title = "Intercellular Mitochondria Transfer to Macrophages Regulates White Adipose Tissue Homeostasis and Is Impaired in Obesity",
abstract = "Brestoff et al. show that adipose-tissue-resident macrophages acquire mitochondria from neighboring adipocytes in a heparan-sulfate-dependent process that is impaired in obesity. Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.",
keywords = "beige adipose tissue, brown adipose tissue, horizontal mitochondria transfer, immunometabolism, intercellular mitochondria transfer, macrophage, metabolism, mitochondria, obesity, white adipose tissue",
author = "Brestoff, {Jonathan R.} and Wilen, {Craig B.} and Moley, {John R.} and Yongjia Li and Wei Zou and Malvin, {Nicole P.} and Rowen, {Marina N.} and Saunders, {Brian T.} and Hongming Ma and Mack, {Madison R.} and Hykes, {Barry L.} and Balce, {Dale R.} and Anthony Orvedahl and Williams, {Jesse W.} and Nidhi Rohatgi and Xiaoyan Wang and McAllaster, {Michael R.} and Handley, {Scott A.} and Kim, {Brian S.} and Doench, {John G.} and Zinselmeyer, {Bernd H.} and Diamond, {Michael S.} and Virgin, {Herbert W.} and Gelman, {Andrew E.} and Teitelbaum, {Steven L.}",
note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
doi = "10.1016/j.cmet.2020.11.008",
language = "English",
journal = "Cell Metabolism",
issn = "1550-4131",
}