Brestoff et al. show that adipose-tissue-resident macrophages acquire mitochondria from neighboring adipocytes in a heparan-sulfate-dependent process that is impaired in obesity. Genetic disruption of mitochondria uptake by macrophages reduces energy expenditure and exacerbates diet-induced obesity in mice, indicating that intercellular mitochondria transfer to macrophages mediates systemic metabolic homeostasis.

Original languageEnglish
Pages (from-to)270-282.e8
JournalCell metabolism
Issue number2
StatePublished - Feb 2 2021


  • beige adipose tissue
  • brown adipose tissue
  • horizontal mitochondria transfer
  • immunometabolism
  • intercellular mitochondria transfer
  • macrophage
  • metabolism
  • mitochondria
  • obesity
  • white adipose tissue


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