Interactions of the immune and sensory nervous systems in atopy

Landon K. Oetjen, Brian S. Kim

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


A striking feature underlying all atopic disorders, such as asthma, atopic dermatitis, and food allergy, is the presence of pathologic sensory responses, reflexes, and behaviors. These symptoms, exemplified by chronic airway irritation and cough, chronic itch and scratching, as well as gastrointestinal discomfort and dysfunction, are often cited as the most debilitating aspects of atopic disorders. Emerging studies have highlighted how the immune system shapes the scope and intensity of sensory responses by directly modulating the sensory nervous system. Additionally, factors produced by neurons have demonstrated novel functions in propagating atopic inflammation at barrier surfaces. In this review, we highlight new studies that have changed our understanding of atopy through advances in characterizing the reciprocal interactions between the immune and sensory nervous systems.

Original languageEnglish
Pages (from-to)3138-3151
Number of pages14
JournalFEBS Journal
Issue number17
StatePublished - Sep 2018


  • allergy
  • asthma
  • atopic dermatitis
  • atopy
  • cytokine
  • neuroimmunology
  • sensory nervous system


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