@article{42d8e8af163b49e29537c273aa4f4b20,
title = "Interactions of genetic variants with physical activity are associated with blood pressure in Chinese: The GenSalt study",
abstract = "BACKGROUND: Blood pressure (BP) homeostasis involves complex interactions among genetic and nongenetic factors, providing major challenges to dissection of the genetic components that influence BP and hypertension. In this study, we examine the effects of interaction of genetic variants with physical activity on BP in a relatively genetically homogenous cohort of rural Chinese villagers. METHODS: Generalized estimating equations analysis was used to test for associations of systolic blood pressure (SBP) and diastolic blood pressure (DBP) with variants in 24 genes in BP pathways (196 single-nucleotide polymorphisms (SNPs)) among 3,142 Chinese participants divided according to physical activity (active vs. inactive groups). RESULTS: In the physically active group, two SNPs in NR3C2 were significantly associated with lower SBP, and a SNP in SCNN1B was significantly associated with lower SBP and DBP. In the physically inactive group, a SNP in APLNR was associated with lower SBP, a SNP in GNB3 (guanine nucleotide binding protein, β polypeptide 3) was associated with higher SBP and DBP, and a SNP in BDKRB2 (bradykinin receptor B2) was associated with lower DBP. Cumulative effects in carriers of minor alleles of these SNPs showed reductions of SBP and DBP as large as 8 and 5mmHg, respectively, in the active individuals compared to inactive individuals carrying the same number of minor alleles. CONCLUSIONS: We found that physical activity modifies the effects of genetic variants on BP. However, our results also show that active individuals with specific genotypes always have lower BP than inactive individuals with the same genotypes, demonstrating the overall beneficial effects of physical activity on BP.",
keywords = "blood pressure, epidemiology, gene by environment interaction, genetics, hypertension, physical activity",
author = "Montasser, {May E.} and Donfeng Gu and Jing Chen and Shimmin, {Lawrence C.} and Charles Gu and Kelly, {Tanika N.} and Jaquish, {Cashell E.} and Treva Rice and Rao, {Dabeeru C.} and Jie Cao and Jichun Chen and Liu, {De Pei} and Whelton, {Paul K.} and Jiang He and Hixson, {James E.}",
note = "Funding Information: supplementary material is linked to the online version of the paper at http://www.nature.com/ajh Acknowledgments: this report is from the Genetic Epidemiology Network of salt sensitivity (Gensalt) study that is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health (U01HL072507). Upsher-smith Laboratories, has provided Klor-Con M20 potassium tablets for the Gensalt study. GenSalt Study Steering Committee: D.G., J.H. (Chair), J.E.H., C.E.J., D.L., D.C.R., p.K.W., and Zhijian Yao. GenSaltCollaborativeResearch Group: tulane University Health sciences Center, New Orleans, UsA—J.H. (pI), Lydia A Bazzano, Chung-shiuan Chen, J.C., Mei Hao, Lee Hamm, t.N.K., paul Muntner, Kristi Reynolds, p.K.W.,WenjieYang, and Qi Zhao.Washington University school of Medicine, st Louis, UsA—D.C.R. (pI), Matthew Brown, C.G., Hongyan Huang, t.R., Karen schwander, and shiping Wang. University of texas Health sciences Center at Houston—J.E.H. (pI) and L.C.s. National Heart, Lung, and Blood Institute—C.E.J. Chinese Academy of Medical sciences, Beijing, China—D.G. (pI), J.C., J.C., Jingping Chen, Zhenhan Du, Jianfeng Huang, Hongwen Jiang, Jianxin Li, Xiaohua Liang, D.L., Xiangfeng Lu, Donghua Liu, Qunxia Mao, Dongling sun, Hongwei Wang, Qianqian Wang, Xigui Wu, Ying Yang, and Dahai Yu. shandong Academy of Medical sciences, shandong, China—Fanghong Lu (pI), Zhendong Liu, shikuan Jin, Yingxin Zhao, shangwen sun, shujian Wang, Qengjie Meng, Baojin Liu, ZhaodongYang, and ChuanruiWei. shandong Center for Diseases Control and prevention, shandong, China—Jixiang Ma (pI), Jiyu Zhang, and Junli tang. Zhengzhou University—Dongsheng Hu, Hongwei Wen, Chongjian Wang, Minghui shen, Jingjing pan, and Liming Yang. Xinle traditional Chinese Medicine Hospital, Hebei, China—Xu Ji (pI), Rongyan Li, Haijun Zu, and Junwei song. Ganyu Center for Disease Control and prevention—Delin Wu (pI), Xushan Wang, and Xiaofeng Zhang. Xi{\textquoteright}an Jiaotong University, shanxi, China—Jianjun Mu (pI), Enrang Chen, Fuqiang Liu, and Guanji Wu. Chinese National Human Genome Center at Beijing—Zhi-JianYao (pI), shufeng Chen, D.G., Hongfan Li, Laiyuan Wang, and penghua Zhang. support—National Institutes of Health grant U01HL072507",
year = "2011",
month = sep,
doi = "10.1038/ajh.2011.97",
language = "English",
volume = "24",
pages = "1035--1040",
journal = "American Journal of Hypertension",
issn = "0895-7061",
number = "9",
}