Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies

Jennifer A. Nettleton; Nicola M. McKeown; Stavroula Kanoni; Rozenn N. Lemaitre; Marie France Hivert; Julius Ngwa; Frank J.A. Van Rooij; Emily Sonestedt; Mary K. Wojczynski; Zheng Ye; Tosh Tanaka; Melissa Garcia; Jennifer S. Anderson; Jack L. Follis; Luc Djousse; Kenneth Mukamal; Constantina Papoutsakis; Dariush Mozaffarian; M. Carola Zillikens; Stefania Bandinelli; Amanda J. Bennett; Ingrid B. Borecki; Mary F. Feitosa; Luigi Ferrucci; Nita G. Forouhi; Christopher J. Groves; Goran Hallmans; Tamara Harris; Albert Hofman; Denise K. Houston; Frank B. Hu; Ingegerd Johansson; Stephen B. Kritchevsky; Claudia Langenberg; Lenore Launer; Yongmei Liu; Ruth J. Loos; Michael Nalls; Marju Orho-Melander; Frida Renstrom; Kenneth Rice; Ulf Riserus; Olov Rolandsson; Jerome I. Rotter; Georgia Saylor; Eric J.G. Sijbrands; Per Sjogren; Albert Smith; Laufey Steingrímsdóttir; André G. Uitterlinden; Nicholas J. Wareham; Inga Prokopenko; James S. Pankow; Cornelia M. Van Duijn; Jose C. Florez; Jacqueline C.M. Witteman; Josée Dupuis; George V. Dedoussis; Jose M. Ordovas; Erik Ingelsson; L. Adrienne Cupples; David S. Siscovick; Paul W. Franks; James B. Meigs

doi:10.2337/dc10-1150

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies

Jennifer A. Nettleton, Nicola M. McKeown, Stavroula Kanoni, Rozenn N. Lemaitre, Marie France Hivert, Julius Ngwa, Frank J.A. Van Rooij, Emily Sonestedt, Mary K. Wojczynski, Zheng Ye, Tosh Tanaka, Melissa Garcia, Jennifer S. Anderson, Jack L. Follis, Luc Djousse, Kenneth Mukamal, Constantina Papoutsakis, Dariush Mozaffarian, M. Carola Zillikens, Stefania BandinelliAmanda J. Bennett, Ingrid B. Borecki, Mary F. Feitosa, Luigi Ferrucci, Nita G. Forouhi, Christopher J. Groves, Goran Hallmans, Tamara Harris, Albert Hofman, Denise K. Houston, Frank B. Hu, Ingegerd Johansson, Stephen B. Kritchevsky, Claudia Langenberg, Lenore Launer, Yongmei Liu, Ruth J. Loos, Michael Nalls, Marju Orho-Melander, Frida Renstrom, Kenneth Rice, Ulf Riserus, Olov Rolandsson, Jerome I. Rotter, Georgia Saylor, Eric J.G. Sijbrands, Per Sjogren, Albert Smith, Laufey Steingrímsdóttir, André G. Uitterlinden, Nicholas J. Wareham, Inga Prokopenko, James S. Pankow, Cornelia M. Van Duijn, Jose C. Florez, Jacqueline C.M. Witteman, Josée Dupuis, George V. Dedoussis, Jose M. Ordovas, Erik Ingelsson, L. Adrienne Cupples, David S. Siscovick, Paul W. Franks, James B. Meigs

Department of Genetics

Research output: Contribution to journal › Review article › peer-review

124 Scopus citations

Abstract

OBJECTIVE - Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS - Via meta-analysis of data from 14 cohorts comprising ∼48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS - Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.

Original language	English
Pages (from-to)	2684-2691
Number of pages	8
Journal	Diabetes care
Volume	33
Issue number	12
DOIs	https://doi.org/10.2337/dc10-1150
State	Published - Dec 2010

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10.2337/dc10-1150

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Nettleton, J. A., McKeown, N. M., Kanoni, S., Lemaitre, R. N., Hivert, M. F., Ngwa, J., Van Rooij, F. J. A., Sonestedt, E., Wojczynski, M. K., Ye, Z., Tanaka, T., Garcia, M., Anderson, J. S., Follis, J. L., Djousse, L., Mukamal, K., Papoutsakis, C., Mozaffarian, D., Zillikens, M. C., ... Meigs, J. B. (2010). Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies. Diabetes care, 33(12), 2684-2691. https://doi.org/10.2337/dc10-1150

@article{4d0b5f0703a24e7e8d411fe943b6d52c,

title = "Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies",

abstract = "OBJECTIVE - Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS - Via meta-analysis of data from 14 cohorts comprising ∼48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS - Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.",

author = "Nettleton, {Jennifer A.} and McKeown, {Nicola M.} and Stavroula Kanoni and Lemaitre, {Rozenn N.} and Hivert, {Marie France} and Julius Ngwa and {Van Rooij}, {Frank J.A.} and Emily Sonestedt and Wojczynski, {Mary K.} and Zheng Ye and Tosh Tanaka and Melissa Garcia and Anderson, {Jennifer S.} and Follis, {Jack L.} and Luc Djousse and Kenneth Mukamal and Constantina Papoutsakis and Dariush Mozaffarian and Zillikens, {M. Carola} and Stefania Bandinelli and Bennett, {Amanda J.} and Borecki, {Ingrid B.} and Feitosa, {Mary F.} and Luigi Ferrucci and Forouhi, {Nita G.} and Groves, {Christopher J.} and Goran Hallmans and Tamara Harris and Albert Hofman and Houston, {Denise K.} and Hu, {Frank B.} and Ingegerd Johansson and Kritchevsky, {Stephen B.} and Claudia Langenberg and Lenore Launer and Yongmei Liu and Loos, {Ruth J.} and Michael Nalls and Marju Orho-Melander and Frida Renstrom and Kenneth Rice and Ulf Riserus and Olov Rolandsson and Rotter, {Jerome I.} and Georgia Saylor and Sijbrands, {Eric J.G.} and Per Sjogren and Albert Smith and Laufey Steingr{\'i}msd{\'o}ttir and Uitterlinden, {Andr{\'e} G.} and Wareham, {Nicholas J.} and Inga Prokopenko and Pankow, {James S.} and {Van Duijn}, {Cornelia M.} and Florez, {Jose C.} and Witteman, {Jacqueline C.M.} and Jos{\'e}e Dupuis and Dedoussis, {George V.} and Ordovas, {Jose M.} and Erik Ingelsson and Cupples, {L. Adrienne} and Siscovick, {David S.} and Franks, {Paul W.} and Meigs, {James B.}",

year = "2010",

month = dec,

doi = "10.2337/dc10-1150",

language = "English",

volume = "33",

pages = "2684--2691",

journal = "Diabetes care",

issn = "0149-5992",

number = "12",

}

Nettleton, JA, McKeown, NM, Kanoni, S, Lemaitre, RN, Hivert, MF, Ngwa, J, Van Rooij, FJA, Sonestedt, E, Wojczynski, MK, Ye, Z, Tanaka, T, Garcia, M, Anderson, JS, Follis, JL, Djousse, L, Mukamal, K, Papoutsakis, C, Mozaffarian, D, Zillikens, MC, Bandinelli, S, Bennett, AJ, Borecki, IB, Feitosa, MF, Ferrucci, L, Forouhi, NG, Groves, CJ, Hallmans, G, Harris, T, Hofman, A, Houston, DK, Hu, FB, Johansson, I, Kritchevsky, SB, Langenberg, C, Launer, L, Liu, Y, Loos, RJ, Nalls, M, Orho-Melander, M, Renstrom, F, Rice, K, Riserus, U, Rolandsson, O, Rotter, JI, Saylor, G, Sijbrands, EJG, Sjogren, P, Smith, A, Steingrímsdóttir, L, Uitterlinden, AG, Wareham, NJ, Prokopenko, I, Pankow, JS, Van Duijn, CM, Florez, JC, Witteman, JCM, Dupuis, J, Dedoussis, GV, Ordovas, JM, Ingelsson, E, Cupples, LA, Siscovick, DS, Franks, PW & Meigs, JB 2010, 'Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies', Diabetes care, vol. 33, no. 12, pp. 2684-2691. https://doi.org/10.2337/dc10-1150

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies. / Nettleton, Jennifer A.; McKeown, Nicola M.; Kanoni, Stavroula et al.
In: Diabetes care, Vol. 33, No. 12, 12.2010, p. 2684-2691.

Research output: Contribution to journal › Review article › peer-review

TY - JOUR

T1 - Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent

T2 - A meta-analysis of 14 cohort studies

AU - Nettleton, Jennifer A.

AU - McKeown, Nicola M.

AU - Kanoni, Stavroula

AU - Lemaitre, Rozenn N.

AU - Hivert, Marie France

AU - Ngwa, Julius

AU - Van Rooij, Frank J.A.

AU - Sonestedt, Emily

AU - Wojczynski, Mary K.

AU - Ye, Zheng

AU - Tanaka, Tosh

AU - Garcia, Melissa

AU - Anderson, Jennifer S.

AU - Follis, Jack L.

AU - Djousse, Luc

AU - Mukamal, Kenneth

AU - Papoutsakis, Constantina

AU - Mozaffarian, Dariush

AU - Zillikens, M. Carola

AU - Bandinelli, Stefania

AU - Bennett, Amanda J.

AU - Borecki, Ingrid B.

AU - Feitosa, Mary F.

AU - Ferrucci, Luigi

AU - Forouhi, Nita G.

AU - Groves, Christopher J.

AU - Hallmans, Goran

AU - Harris, Tamara

AU - Hofman, Albert

AU - Houston, Denise K.

AU - Hu, Frank B.

AU - Johansson, Ingegerd

AU - Kritchevsky, Stephen B.

AU - Langenberg, Claudia

AU - Launer, Lenore

AU - Liu, Yongmei

AU - Loos, Ruth J.

AU - Nalls, Michael

AU - Orho-Melander, Marju

AU - Renstrom, Frida

AU - Rice, Kenneth

AU - Riserus, Ulf

AU - Rolandsson, Olov

AU - Rotter, Jerome I.

AU - Saylor, Georgia

AU - Sijbrands, Eric J.G.

AU - Sjogren, Per

AU - Smith, Albert

AU - Steingrímsdóttir, Laufey

AU - Uitterlinden, André G.

AU - Wareham, Nicholas J.

AU - Prokopenko, Inga

AU - Pankow, James S.

AU - Van Duijn, Cornelia M.

AU - Florez, Jose C.

AU - Witteman, Jacqueline C.M.

AU - Dupuis, Josée

AU - Dedoussis, George V.

AU - Ordovas, Jose M.

AU - Ingelsson, Erik

AU - Cupples, L. Adrienne

AU - Siscovick, David S.

AU - Franks, Paul W.

AU - Meigs, James B.

PY - 2010/12

Y1 - 2010/12

N2 - OBJECTIVE - Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS - Via meta-analysis of data from 14 cohorts comprising ∼48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS - Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.

AB - OBJECTIVE - Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single nucleotide polymorphisms (SNPs) associated with fasting glucose and insulin concentrations in individuals free of diabetes. We tested the hypothesis that whole-grain food intake and genetic variation interact to influence concentrations of fasting glucose and insulin. RESEARCH DESIGN AND METHODS - Via meta-analysis of data from 14 cohorts comprising ∼48,000 participants of European descent, we studied interactions of whole-grain intake with loci previously associated in GWAS with fasting glucose (16 loci) and/or insulin (2 loci) concentrations. For tests of interaction, we considered a P value <0.0028 (0.05 of 18 tests) as statistically significant. RESULTS - Greater whole-grain food intake was associated with lower fasting glucose and insulin concentrations independent of demographics, other dietary and lifestyle factors, and BMI (β [95% CI] per 1-serving-greater whole-grain intake: -0.009 mmol/l glucose [-0.013 to -0.005], P < 0.0001 and -0.011 pmol/l [ln] insulin [-0.015 to -0.007], P = 0.0003). No interactions met our multiple testing-adjusted statistical significance threshold. The strongest SNP interaction with whole-grain intake was rs780094 (GCKR) for fasting insulin (P = 0.006), where greater whole-grain intake was associated with a smaller reduction in fasting insulin concentrations in those with the insulin-raising allele.

UR - http://www.scopus.com/inward/record.url?scp=77958562031&partnerID=8YFLogxK

U2 - 10.2337/dc10-1150

DO - 10.2337/dc10-1150

M3 - Review article

C2 - 20693352

AN - SCOPUS:77958562031

SN - 0149-5992

VL - 33

SP - 2684

EP - 2691

JO - Diabetes care

JF - Diabetes care

IS - 12

ER -

Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: A meta-analysis of 14 cohort studies

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