TY - JOUR
T1 - Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck.
AU - Vignali, D. A.
AU - Doyle, C.
AU - Kinch, M. S.
AU - Shin, J.
AU - Strominger, J. L.
PY - 1993/10/29
Y1 - 1993/10/29
N2 - CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.
AB - CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.
UR - http://www.scopus.com/inward/record.url?scp=0027925922&partnerID=8YFLogxK
U2 - 10.1098/rstb.1993.0130
DO - 10.1098/rstb.1993.0130
M3 - Review article
C2 - 7506833
AN - SCOPUS:0027925922
VL - 342
SP - 13
EP - 24
JO - Philosophical Transactions of the Royal Society B: Biological Sciences
JF - Philosophical Transactions of the Royal Society B: Biological Sciences
SN - 0962-8436
IS - 1299
ER -