Abstract
CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.
| Original language | English |
|---|---|
| Pages (from-to) | 13-24 |
| Number of pages | 12 |
| Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences |
| Volume | 342 |
| Issue number | 1299 |
| DOIs | |
| State | Published - Oct 29 1993 |
| Externally published | Yes |
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Vignali, D. A., Doyle, C., Kinch, M. S., Shin, J., & Strominger, J. L. (1993). Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 342(1299), 13-24. https://doi.org/10.1098/rstb.1993.0130