Interactions of CD4 with MHC class II molecules, T cell receptors and p56lck.

D. A. Vignali, C. Doyle, M. S. Kinch, J. Shin, J. L. Strominger

Research output: Contribution to journalReview articlepeer-review

11 Scopus citations


CD4 and CD8 are members of the immunoglobulin supergene family of proteins, and function as co-receptors with the T cell receptor (TCR) in binding MHC class II or class I molecules, respectively. Within this multimeric complex, CD4 interacts with three distinct ligands. CD4 interacts through its D1 and D2 domains with MHC class II proteins, through its D3 and D4 domains with T cell receptors, and through its cytoplasmic tail with p56lck, a src-related, protein tyrosine kinase. Each of these interactions is important in the function of CD4 and will be discussed in turn.

Original languageEnglish
Pages (from-to)13-24
Number of pages12
JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences
Issue number1299
StatePublished - Oct 29 1993


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