TY - JOUR
T1 - Interactions between noroviruses, the host, and the microbiota
AU - Walker, Forrest C.
AU - Baldridge, Megan T.
N1 - Funding Information:
This work was supported by the National Institutes of Health (NIH) grants R01AI141478 , R01AI139314 , and R01AI127552 , Digestive Diseases Research Core Centers P30 DK052574 , and the Pew Biomedical Scholars Program . F.C.W. was supported by NIH T32GM007067 .
Publisher Copyright:
© 2019 Elsevier B.V.
PY - 2019/8
Y1 - 2019/8
N2 - In recent years, appreciation has been growing for the role that the microbiota plays in interactions between the host and various pathogens, including norovirus. Proviral and antiviral effects of the microbiota have been observed for both human and murine noroviruses, and it has become clear that direct effects of microbes and their metabolites as well as indirect effects of commensals on the host are key in modulating pathogenesis. In particular, a common thread has emerged in the ability of members of the microbiota to regulate the host interferon response, thereby modulating norovirus infection. Here, we highlight key differences between human and murine noroviruses and their interactions with the microbiota, while also underscoring shared characteristics between noroviruses and other gastrointestinal viruses.
AB - In recent years, appreciation has been growing for the role that the microbiota plays in interactions between the host and various pathogens, including norovirus. Proviral and antiviral effects of the microbiota have been observed for both human and murine noroviruses, and it has become clear that direct effects of microbes and their metabolites as well as indirect effects of commensals on the host are key in modulating pathogenesis. In particular, a common thread has emerged in the ability of members of the microbiota to regulate the host interferon response, thereby modulating norovirus infection. Here, we highlight key differences between human and murine noroviruses and their interactions with the microbiota, while also underscoring shared characteristics between noroviruses and other gastrointestinal viruses.
UR - http://www.scopus.com/inward/record.url?scp=85065491974&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2019.04.001
DO - 10.1016/j.coviro.2019.04.001
M3 - Review article
C2 - 31096124
AN - SCOPUS:85065491974
SN - 1879-6257
VL - 37
SP - 1
EP - 9
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -