Interactions between lymphocytes and myeloid cells regulate pro-versus anti-tumor immunity

David G. DeNardo, Pauline Andreu, Lisa M. Coussens

Research output: Contribution to journalReview article

288 Scopus citations

Abstract

Tumor-associated myeloid cells have been implicated in regulating many of the "hallmarks of cancer" and thus fostering solid tumor development and metastasis. However, the same innate leukocytes also participate in anti-tumor immunity and restraint of malignant disease. While many factors regulate the propensity of myeloid cells to promote or repress cancerous growths, polarized adaptive immune responses by B and T lymphocytes have been identified as regulators of many aspects of myeloid cell biology by specifically regulating their functional capabilities. Here, we detail the diversity of heterogeneous B and T lymphocyte populations and their impacts on solid tumor development through their abilities to regulate myeloid cell function in solid tumors.

Original languageEnglish
Pages (from-to)309-316
Number of pages8
JournalCancer and Metastasis Reviews
Volume29
Issue number2
DOIs
StatePublished - Jun 1 2010
Externally publishedYes

Keywords

  • Cancer
  • Inflammation
  • Lymphocyte
  • Macrophage
  • Metastasis

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