Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis

Kate L.J. Ellacott; Ilia G. Halatchev; Roger D. Cone

doi:10.1016/j.peptides.2005.02.031

Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis

Kate L.J. Ellacott, Ilia G. Halatchev, Roger D. Cone

Research output: Contribution to journal › Review article › peer-review

44 Scopus citations

Abstract

Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY_3-36.

Original language	English
Pages (from-to)	340-349
Number of pages	10
Journal	Peptides
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.peptides.2005.02.031
State	Published - Feb 2006

Keywords

Cholecystokinin
Food intake
Ghrelin
PYY
Proopiomelanocortin
Satiety

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10.1016/j.peptides.2005.02.031

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title = "Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis",

abstract = "Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY3-36.",

keywords = "Cholecystokinin, Food intake, Ghrelin, PYY, Proopiomelanocortin, Satiety",

author = "Ellacott, {Kate L.J.} and Halatchev, {Ilia G.} and Cone, {Roger D.}",

note = "Funding Information: We gratefully acknowledge the support of the NIH/NIDDK (R.D.C., I.G.H.) and the Wellcome Trust fellowship #068303 (K.L.J.E.).",

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AU - Ellacott, Kate L.J.

AU - Halatchev, Ilia G.

AU - Cone, Roger D.

N1 - Funding Information: We gratefully acknowledge the support of the NIH/NIDDK (R.D.C., I.G.H.) and the Wellcome Trust fellowship #068303 (K.L.J.E.).

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N2 - Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY3-36.

AB - Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY3-36.

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KW - Food intake

KW - Ghrelin

KW - PYY

KW - Proopiomelanocortin

KW - Satiety

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DO - 10.1016/j.peptides.2005.02.031

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Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis

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Keywords

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