Interactions between gut peptides and the central melanocortin system in the regulation of energy homeostasis

Kate L.J. Ellacott, Ilia G. Halatchev, Roger D. Cone

Research output: Contribution to journalReview article

39 Scopus citations

Abstract

Genetic and pharmacological studies have shown that the central melanocortin system plays a critical role in the regulation of energy homeostasis. Animals and humans with defects in the central melanocortin system display a characteristic melanocortin obesity phenotype typified by increased adiposity, hyperphagia, metabolic defects and increased linear growth. In addition to interacting with long-term regulators of energy homeostasis such as leptin, more recent data suggest that the central melanocortin system also responds to gut-released peptides involved in mediating satiety. In this review, we discuss the interactions between these systems, with particular emphasis on cholecystokinin (CCK), ghrelin and PYY3-36.

Original languageEnglish
Pages (from-to)340-349
Number of pages10
JournalPeptides
Volume27
Issue number2
DOIs
StatePublished - Feb 1 2006
Externally publishedYes

Keywords

  • Cholecystokinin
  • Food intake
  • Ghrelin
  • PYY
  • Proopiomelanocortin
  • Satiety

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