Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs

J. R. Sheller, M. J. Holtzman, B. E. Skoogh, J. A. Nadel

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The bronchoconstrictor response to electrical stimulation of the peripheral ends of both cut cervical vagus nerves was potentiated by serotonin aerosols in 10 experiments in 7 anesthetized dogs. The bronchoconstrictor response to acetylcholine (ACh) aerosols was unchanged after serotonin. We conclude that serotonin acts at the level of the parasympathetic ganglia or the postganglionic nerve terminal to potentiate the bronchoconstrictor response to vagal stimulation.

Original languageEnglish
Pages (from-to)964-966
Number of pages3
JournalJournal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume52
Issue number4
DOIs
StatePublished - 1982

Fingerprint

Dive into the research topics of 'Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs'. Together they form a unique fingerprint.

Cite this