Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs

J. R. Sheller; M. J. Holtzman; B. E. Skoogh; J. A. Nadel

doi:10.1152/jappl.1982.52.4.964

Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs

J. R. Sheller, M. J. Holtzman, B. E. Skoogh, J. A. Nadel

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Abstract

The bronchoconstrictor response to electrical stimulation of the peripheral ends of both cut cervical vagus nerves was potentiated by serotonin aerosols in 10 experiments in 7 anesthetized dogs. The bronchoconstrictor response to acetylcholine (ACh) aerosols was unchanged after serotonin. We conclude that serotonin acts at the level of the parasympathetic ganglia or the postganglionic nerve terminal to potentiate the bronchoconstrictor response to vagal stimulation.

Original language	English
Pages (from-to)	964-966
Number of pages	3
Journal	Journal of Applied Physiology Respiratory Environmental and Exercise Physiology
Volume	52
Issue number	4
DOIs	https://doi.org/10.1152/jappl.1982.52.4.964
State	Published - 1982

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10.1152/jappl.1982.52.4.964

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abstract = "The bronchoconstrictor response to electrical stimulation of the peripheral ends of both cut cervical vagus nerves was potentiated by serotonin aerosols in 10 experiments in 7 anesthetized dogs. The bronchoconstrictor response to acetylcholine (ACh) aerosols was unchanged after serotonin. We conclude that serotonin acts at the level of the parasympathetic ganglia or the postganglionic nerve terminal to potentiate the bronchoconstrictor response to vagal stimulation.",

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Interaction of serotonin with vagal- and ACh-induced bronchoconstriction in canine lungs

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