Interaction of antibiotics and warfarin in pediatric cardiology patients

M. C. Johnson; M. Wood; V. Vaughn; L. Cowan; A. M. Sharkey

doi:10.1007/s00246-005-0819-5

Interaction of antibiotics and warfarin in pediatric cardiology patients

M. C. Johnson, M. Wood, V. Vaughn, L. Cowan, A. M. Sharkey

Research output: Contribution to journal › Review article › peer-review

12 Scopus citations

Abstract

Antibiotics are known to alter the anticoagulation induced by warfarin in adults, but little is known about this interaction in children. In a retrospective review of patients under the age of 21 years, we found that antibiotic therapy (89 courses of antibiotics in 23 patients) was associated with an increase in the mean international normalized ratio (INR) from 2.7 to 3.6. The change in INR correlated inversely with patient age. These data suggest that more intensive monitoring of the INR after starting antibiotics may help to mitigate excessive anticoagulation in children receiving warfarin.

Original language	English
Pages (from-to)	589-592
Number of pages	4
Journal	Pediatric Cardiology
Volume	26
Issue number	5
DOIs	https://doi.org/10.1007/s00246-005-0819-5
State	Published - Oct 1 2005

Keywords

Antibiotics
Anticoagulation
Warfarin

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10.1007/s00246-005-0819-5

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abstract = "Antibiotics are known to alter the anticoagulation induced by warfarin in adults, but little is known about this interaction in children. In a retrospective review of patients under the age of 21 years, we found that antibiotic therapy (89 courses of antibiotics in 23 patients) was associated with an increase in the mean international normalized ratio (INR) from 2.7 to 3.6. The change in INR correlated inversely with patient age. These data suggest that more intensive monitoring of the INR after starting antibiotics may help to mitigate excessive anticoagulation in children receiving warfarin.",

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AU - Wood, M.

AU - Vaughn, V.

AU - Cowan, L.

AU - Sharkey, A. M.

PY - 2005/10/1

Y1 - 2005/10/1

N2 - Antibiotics are known to alter the anticoagulation induced by warfarin in adults, but little is known about this interaction in children. In a retrospective review of patients under the age of 21 years, we found that antibiotic therapy (89 courses of antibiotics in 23 patients) was associated with an increase in the mean international normalized ratio (INR) from 2.7 to 3.6. The change in INR correlated inversely with patient age. These data suggest that more intensive monitoring of the INR after starting antibiotics may help to mitigate excessive anticoagulation in children receiving warfarin.

AB - Antibiotics are known to alter the anticoagulation induced by warfarin in adults, but little is known about this interaction in children. In a retrospective review of patients under the age of 21 years, we found that antibiotic therapy (89 courses of antibiotics in 23 patients) was associated with an increase in the mean international normalized ratio (INR) from 2.7 to 3.6. The change in INR correlated inversely with patient age. These data suggest that more intensive monitoring of the INR after starting antibiotics may help to mitigate excessive anticoagulation in children receiving warfarin.

KW - Antibiotics

KW - Anticoagulation

KW - Warfarin

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JO - Pediatric Cardiology

JF - Pediatric Cardiology

IS - 5

ER -

Interaction of antibiotics and warfarin in pediatric cardiology patients

Abstract

Keywords

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