Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia

Children’s Hospitals Neonatal Consortium Intestinal Failure Focus Group

doi:10.1038/s41372-025-02481-0

Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia

Children’s Hospitals Neonatal Consortium Intestinal Failure Focus Group

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: To quantify inter-center variation (ICV) in length of stay (LOS) among surviving infants with jejunal (JA) or ileal atresia (IA). Study design: Children’s Hospitals Neonatal Consortium’s database was used to identify infants with JA or IA. After excluding infants with abdominal wall defects, survivors’ hospital LOS was modeled as a function of center using generalized linear models with log link for gamma distribution. Results: There were 1134 and 808 infants with JA and IA, respectively. LOS had significant ICV in unadjusted (JA: 5.4 [IQR 3.7,9.9] weeks; IA: 4.3 [IQR 2.4,11.4] weeks) and multivariable analyses (JA: 4+ fold difference (6.5–31.5 week); p < 0.001 IA: 8+ fold difference (1.7–14.6 weeks); p < 0.001) with modifiable risk factors including cholestasis, ostomy creation, blood stream infection, and residual bowel length <55 cm. Conclusion: Risk-adjusted ICV in LOS was observed in infants with JA and IA, which exposes opportunities for improvements in outcomes for infants with intestinal atresia.

Original language	English
Journal	Journal of Perinatology
DOIs	https://doi.org/10.1038/s41372-025-02481-0
State	Accepted/In press - 2025

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10.1038/s41372-025-02481-0

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@article{1ad44ccd519542289c185e052e77bc88,

title = "Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia",

abstract = "Objective: To quantify inter-center variation (ICV) in length of stay (LOS) among surviving infants with jejunal (JA) or ileal atresia (IA). Study design: Children{\textquoteright}s Hospitals Neonatal Consortium{\textquoteright}s database was used to identify infants with JA or IA. After excluding infants with abdominal wall defects, survivors{\textquoteright} hospital LOS was modeled as a function of center using generalized linear models with log link for gamma distribution. Results: There were 1134 and 808 infants with JA and IA, respectively. LOS had significant ICV in unadjusted (JA: 5.4 [IQR 3.7,9.9] weeks; IA: 4.3 [IQR 2.4,11.4] weeks) and multivariable analyses (JA: 4+ fold difference (6.5–31.5 week); p < 0.001 IA: 8+ fold difference (1.7–14.6 weeks); p < 0.001) with modifiable risk factors including cholestasis, ostomy creation, blood stream infection, and residual bowel length <55 cm. Conclusion: Risk-adjusted ICV in LOS was observed in infants with JA and IA, which exposes opportunities for improvements in outcomes for infants with intestinal atresia.",

author = "\{Children{\textquoteright}s Hospitals Neonatal Consortium Intestinal Failure Focus Group\} and Huff, \{Katie A.\} and Isabella Zaniletti and Kera McNelis and Alan Ladd and Abeer Azzuqa and Coghill, \{Carl H.\} and Robinson, \{Daniel T.\} and Premkumar, \{Muralidhar H.\} and Denning, \{Patricia W.\} and Jae Kim and Corkins, \{Mark R.\} and Andrea Adler and Darren Bodkin and Jeffrey Rudolph and Ashley Moore and Strobel, \{Katie M.\} and Padula, \{Michael A.\} and Grover, \{Theresa R.\} and Karna Murthy and Nayak, \{Sujir Pritha\} and Cherrie Welch and Kevin Sullivan and Short, \{Billie Lou\} and Lee, \{Kyong Soon\} and \{Van Marter\}, Linda and Ann Downey and Rakesh Rao and Beverly Brozanski and Elizabeth Jacobsen and Robert DiGeronimo and Mark Speziale and Ling, \{Con Yee\} and Ellen Bendel-Stenzel and Toby Yanowitz and Pam Griffiths and Vilarmis Quinones and Michael Padula and Aaron Weiss and Rajan Wadhawan and Narendra Dereddy and Michel Mikhael and Nicole Birge and Patricia Williams and Trent Tipple and Priscilla Joe and Joanne Lagatta and Mark Weems and Nina Menda and Rachel Chapman and Laura Carroll and Julie Weiner and Julie Lindower and Rebecca Rose and Kristina Reber and Annmarie Gotiolo and Yvette Johnson and Annie Chi and Girija Natarajan and Stephanie Bourque and Danielle Smith and Lina Chalak and Sushmita Yallapragada and Thomas Bartman and Ceyda Acun and Beth Haberman and Gustave Falciglia and Karna Murthy and Eugenia Pallotto and Anne Hansen and Carl Coghill and Allison Black and Molly Pont and Ashley Lucke and Gregory Sysyn and Anthony Piazza",

note = "Publisher Copyright: {\textcopyright} The Author(s), under exclusive licence to Springer Nature America, Inc. 2025.",

year = "2025",

doi = "10.1038/s41372-025-02481-0",

language = "English",

journal = "Journal of Perinatology",

issn = "0743-8346",

}

TY - JOUR

T1 - Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia

AU - Children’s Hospitals Neonatal Consortium Intestinal Failure Focus Group

AU - Huff, Katie A.

AU - Zaniletti, Isabella

AU - McNelis, Kera

AU - Ladd, Alan

AU - Azzuqa, Abeer

AU - Coghill, Carl H.

AU - Robinson, Daniel T.

AU - Premkumar, Muralidhar H.

AU - Denning, Patricia W.

AU - Kim, Jae

AU - Corkins, Mark R.

AU - Adler, Andrea

AU - Bodkin, Darren

AU - Rudolph, Jeffrey

AU - Moore, Ashley

AU - Strobel, Katie M.

AU - Padula, Michael A.

AU - Grover, Theresa R.

AU - Murthy, Karna

AU - Nayak, Sujir Pritha

AU - Welch, Cherrie

AU - Sullivan, Kevin

AU - Short, Billie Lou

AU - Lee, Kyong Soon

AU - Van Marter, Linda

AU - Downey, Ann

AU - Rao, Rakesh

AU - Brozanski, Beverly

AU - Jacobsen, Elizabeth

AU - DiGeronimo, Robert

AU - Speziale, Mark

AU - Ling, Con Yee

AU - Bendel-Stenzel, Ellen

AU - Yanowitz, Toby

AU - Griffiths, Pam

AU - Quinones, Vilarmis

AU - Padula, Michael

AU - Weiss, Aaron

AU - Wadhawan, Rajan

AU - Dereddy, Narendra

AU - Mikhael, Michel

AU - Birge, Nicole

AU - Williams, Patricia

AU - Tipple, Trent

AU - Joe, Priscilla

AU - Lagatta, Joanne

AU - Weems, Mark

AU - Menda, Nina

AU - Chapman, Rachel

AU - Carroll, Laura

AU - Weiner, Julie

AU - Lindower, Julie

AU - Rose, Rebecca

AU - Reber, Kristina

AU - Gotiolo, Annmarie

AU - Johnson, Yvette

AU - Chi, Annie

AU - Natarajan, Girija

AU - Bourque, Stephanie

AU - Smith, Danielle

AU - Chalak, Lina

AU - Yallapragada, Sushmita

AU - Bartman, Thomas

AU - Acun, Ceyda

AU - Haberman, Beth

AU - Falciglia, Gustave

AU - Murthy, Karna

AU - Pallotto, Eugenia

AU - Hansen, Anne

AU - Coghill, Carl

AU - Black, Allison

AU - Pont, Molly

AU - Lucke, Ashley

AU - Sysyn, Gregory

AU - Piazza, Anthony

PY - 2025

Y1 - 2025

N2 - Objective: To quantify inter-center variation (ICV) in length of stay (LOS) among surviving infants with jejunal (JA) or ileal atresia (IA). Study design: Children’s Hospitals Neonatal Consortium’s database was used to identify infants with JA or IA. After excluding infants with abdominal wall defects, survivors’ hospital LOS was modeled as a function of center using generalized linear models with log link for gamma distribution. Results: There were 1134 and 808 infants with JA and IA, respectively. LOS had significant ICV in unadjusted (JA: 5.4 [IQR 3.7,9.9] weeks; IA: 4.3 [IQR 2.4,11.4] weeks) and multivariable analyses (JA: 4+ fold difference (6.5–31.5 week); p < 0.001 IA: 8+ fold difference (1.7–14.6 weeks); p < 0.001) with modifiable risk factors including cholestasis, ostomy creation, blood stream infection, and residual bowel length <55 cm. Conclusion: Risk-adjusted ICV in LOS was observed in infants with JA and IA, which exposes opportunities for improvements in outcomes for infants with intestinal atresia.

AB - Objective: To quantify inter-center variation (ICV) in length of stay (LOS) among surviving infants with jejunal (JA) or ileal atresia (IA). Study design: Children’s Hospitals Neonatal Consortium’s database was used to identify infants with JA or IA. After excluding infants with abdominal wall defects, survivors’ hospital LOS was modeled as a function of center using generalized linear models with log link for gamma distribution. Results: There were 1134 and 808 infants with JA and IA, respectively. LOS had significant ICV in unadjusted (JA: 5.4 [IQR 3.7,9.9] weeks; IA: 4.3 [IQR 2.4,11.4] weeks) and multivariable analyses (JA: 4+ fold difference (6.5–31.5 week); p < 0.001 IA: 8+ fold difference (1.7–14.6 weeks); p < 0.001) with modifiable risk factors including cholestasis, ostomy creation, blood stream infection, and residual bowel length <55 cm. Conclusion: Risk-adjusted ICV in LOS was observed in infants with JA and IA, which exposes opportunities for improvements in outcomes for infants with intestinal atresia.

UR - https://www.scopus.com/pages/publications/105025102722

U2 - 10.1038/s41372-025-02481-0

DO - 10.1038/s41372-025-02481-0

M3 - Article

C2 - 41310308

AN - SCOPUS:105025102722

SN - 0743-8346

JO - Journal of Perinatology

JF - Journal of Perinatology

ER -

Inter-center variations in length of hospitalization for infants with congenital jejunal or ileal atresia

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