Intentional fracture of bioprosthetic valve frames in patients undergoing valve-in-valve transcatheter pulmonary valve replacement

Shabana Shahanavaz, Jeremy D. Asnes, Jochen Grohmann, Athar M. Qureshi, Jonathan J. Rome, Daniel Tanase, Matthew A. Crystal, Larry A. Latson, Brian H. Morray, William Hellenbrand, David T. Balzer, Marc Gewillig, Jon C. Love, Farhouch Berdjis, Matthew J. Gillespie, Doff B. McElhinney

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


BACKGROUND: Percutaneous transcatheter pulmonary valve replacement (TPVR) has good clinical and hemodynamic outcomes in treating dysfunctional bioprosthetic valves (BPV) in the pulmonary position. Valve-in-valve therapy can further decrease the inner diameter (ID), potentially resulting in patient-prosthesis mismatch in patients with smaller BPVs. METHODS AND RESULTS: To evaluate feasibility and outcomes of intentional BPV fracture to enlarge the pulmonary valve orifice with TPVR, 37 patients from 13 centers who underwent TPVR with intended BPV fracture were evaluated. A control cohort (n=70) who underwent valve-in-valve TPVR without attempted fracture was evaluated. BPV was successfully fractured in 28 patients and stretched in 5 while fracture was unsuccessful in 4. A Melody valve was implanted in 25 patients with fractured/stretched frame and a Sapien (XT 3) valve in 8. Among patients whose BPV was fractured/stretched, the final ID was a median of 2 mm larger (0-6.5 mm) than the valve's true ID. The narrowest diameter after TPVR in controls was a median of 2 mm smaller (P<0.001) than true ID. Right ventricular outflow tract gradient decreased from median 40 to 8 mmHg in the fracture group. Cases with fracture/stretching were matched 1:1 (weight, true ID) to controls. Post-TPVR peak gradient was lower but not significant (8.3±5.2 versus 11.8±9.2 mmHg; P=0.070). There were no fracture-related adverse events. CONCLUSIONS: Preliminary experience shows intentional fracture of BPV frame can be useful for achieving larger ID and better hemodynamics after valve-in-valve TPVR.

Original languageEnglish
Article numbere006453
JournalCirculation: Cardiovascular Interventions
Issue number8
StatePublished - 2018


  • Hemodynamics
  • Prostheses and implants
  • Pulmonary valve
  • Stents
  • Tetralogy of Fallot


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